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Safety Information

W398403

Sigma-Aldrich

4-Hydroxybenzaldehyde

≥97%, FG

Synonym(s):

p-Hydroxybenzaldehyde

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About This Item

Linear Formula:
HOC6H4CHO
CAS Number:
123-08-0
Molecular Weight:
122.12
FEMA Number:
3984
Beilstein:
471352
EC Number:
204-599-1
MDL number:
MFCD00006939
UNSPSC Code:
12164502
PubChem Substance ID:
24901959
Flavis number:
5.047
NACRES:
NA.21
Organoleptic:
almond; balsamic; nutty; sweet
grade:
FG
Fragrance grade
Halal
Kosher
biological source:
synthetic
Agency:
follows IFRA guidelines
food allergen:
no known allergens

biological source

synthetic

Quality Level

400

grade

FG
Fragrance grade
Halal
Kosher

Agency

follows IFRA guidelines

reg. compliance

EU Regulation 1223/2009
EU Regulation 1334/2008 & 872/2012
FDA 21 CFR 110

Assay

≥97%

mp

112-116 °C (lit.)

application(s)

flavors and fragrances

Documentation

see Safety & Documentation for available documents

food allergen

no known allergens

fragrance allergen

no known allergens

Organoleptic

almond; balsamic; nutty; sweet

SMILES string

[H]C(=O)c1ccc(O)cc1

InChI

1S/C7H6O2/c8-5-6-1-3-7(9)4-2-6/h1-5,9H

InChI key

RGHHSNMVTDWUBI-UHFFFAOYSA-N

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General description

4-hydroxybenzaldehyde occurs naturally in vanilla beans and is one of the keys contributors to the vanilla flavor.

Application

  • Dual action of benzaldehydes: Inhibiting quorum sensing and enhancing antibiotic efficacy for controlling Pseudomonas aeruginosa biofilms.: This paper highlights the dual functionality of benzaldehyde derivatives in inhibiting bacterial communication and boosting antibiotic efficiency, offering promising strategies against biofilm-associated infections (Borges A et al., 2024).

Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H318,H335

Hazard Classifications

Eye Dam. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

345.2 °F

Flash Point(C)

174 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

W398403-1KG:
W398403-VAR-K:
W398403-5KG-K:4548173980850
W398403-10KG-K:4548173980836
W398403-1KG-K:4548173980843
W398403-10KG:
W398403-SAMPLE:
W398403-BULK-K:
W398403-SAMPLE-K:
W398403-5KG:

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Certificates of Analysis (COA)

Lot/Batch Number
SHBR4170
SHBR6947
SHBQ4889
SHBP1002
SHBP6302

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Unusual 4-hydroxybenzaldehyde synthase activity from tissue cultures of the vanilla orchid Vanilla planifolia.
Podstolski A, et al.
Phytochemistry, 61(6), 611-620 (2002)
Huan Wen et al.
European journal of medicinal chemistry, 43(1), 166-173 (2007-06-19)
A series of helicid analogues were prepared and evaluated in vitro for the cholinesterase (AChE and BuChE) inhibitory activities via UV spectroscopy. The results indicated that compounds 5, 6d and 8 exhibited potent AChE inhibitory activities with IC(50) values of
Nadja Schultz-Jensen et al.
Applied biochemistry and biotechnology, 165(3-4), 1010-1023 (2011-07-06)
The potential of wheat straw for ethanol production after pretreatment with O(3) generated in a plasma at atmospheric pressure and room temperature followed by fermentation was investigated. We found that cellulose and hemicellulose remained unaltered after ozonisation and a subsequent
Wei Yi et al.
European journal of medicinal chemistry, 45(2), 639-646 (2009-11-26)
A series of novel 4-hydroxybenzaldehyde derivatives were synthesized and their inhibitory effects on the diphenolase activity of mushroom tyrosinase were investigated. Most of target compounds had more potent inhibitory activities than the parent compound 4-hydroxybenzaldehyde (IC(50)=1.22 mM). Interestingly, compound 3c
Sunmin Park et al.
European journal of nutrition, 50(2), 107-118 (2010-06-26)
Insulin resistance is a common symptom of metabolic diseases such as obesity, type 2 diabetes and hyperlipidemia. We investigated whether Gastrodia elata Blume water extract(GEB), containing phenolic compounds, had a beneficial action on insulin resistance in male Sprague-Dawley rats fed
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