Skip to Content
Merck
All Photos(1)

Key Documents

Safety Information

700184M

Avanti

desmosterol (D6) ester

26,26,26,27,27,27-hexadeuteriocholesta-5,24-dien-3β-ol (9Z-octadecenoate), methylene chloride solution

Synonym(s):

111014

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C45H70D6O2
CAS Number:
2260669-31-4
Molecular Weight:
655.12
UNSPSC Code:
12352211
NACRES:
NA.12

Assay

>99% (TLC)

form

methylene chloride solution

packaging

pkg of 1 × 1 mL (700184M-1mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 700184M

concentration

1 mg/mL (700184M-1mg)

shipped in

dry ice

storage temp.

−20°C

General description

Desmosterol is a precursor of cholesterol synthesis and the enzyme 24-dehydrocholesterol reductase catalyzes this step. It lacks a double bond between C24 and C25, which is present in cholesterol. Desmosterol is the major brain sterol and is localized in spermatozoa membrane and astrocytes. Desmosterol (D6) ester is a deuterated desmosterol with octadecanoic acid.

Biochem/physiol Actions

Desmosterol is a liver X receptor (LXR) agonist and it regulates inflammatory signaling in macrophages. Desmosterol accumulates during impairment of 24-dehydrocholesterol reductase enzyme thereby leading to desmosterolosis. It is a potential therapeutic target for treating the neurodegenerative disorder.

Packaging

5 mL Clear Glass Sealed Ampule (700184M-1mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H336,H351

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Central nervous system

WGK

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

700184M-BULK:
700184M-VAR:
700184M-1MG:4548173373157

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service