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Safety Information

T-049

Supelco

Tacrolimus solution

1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirical Formula (Hill Notation):
C44H69NO12
CAS Number:
104987-11-3
Molecular Weight:
804.02
MDL number:
MFCD00869853
UNSPSC Code:
41116107
PubChem Substance ID:
329826607
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in acetonitrile

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−70°C

SMILES string

CO[C@@H]1C[C@@H](CC[C@H]1O)\C=C(/C)[C@H]2OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@]4(O)O[C@H]([C@H](C[C@@H](C)C\C(C)=C\[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)OC)[C@H](C[C@H]4C)OC

InChI

1S/C44H69NO12/c1-10-13-31-19-25(2)18-26(3)20-37(54-8)40-38(55-9)22-28(5)44(52,57-40)41(49)42(50)45-17-12-11-14-32(45)43(51)56-39(29(6)34(47)24-35(31)48)27(4)21-30-15-16-33(46)36(23-30)53-7/h10,19,21,26,28-34,36-40,46-47,52H,1,11-18,20,22-24H2,2-9H3/b25-19+,27-21+/t26-,28+,29+,30-,31+,32-,33+,34-,36+,37-,38-,39+,40+,44+/m0/s1

InChI key

QJJXYPPXXYFBGM-LFZNUXCKSA-N

Gene Information

human ... FKBP1A(2280)

Related Categories

General description

Tacrolimus, also known as fujimycin, is an immunosuppressant used to prevent rejection of organ transplants. This Certified Spiking Solution® is suitable for use as starting material in the preparation of calibrators and controls for tacrolimus testing methods by LC-MS/MS. Tacrolimus is sold under trade names Progaf, Advagraf®, and Protopic®.

Legal Information

Advagraf is a registered trademark of Astellas Pharma Inc.
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Protopic is a registered trademark of Astellas Pharma Inc.
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameExclamation mark
GHS02,GHS07

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

35.6 °F - closed cup

Flash Point(C)

2 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water insoluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

T-049-CC:
T-049-1ML:4548173334424

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Certificates of Analysis (COA)

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A Osama Gaber et al.
Transplantation, 96(2), 191-197 (2013-05-30)
LCP-Tacro is an extended-release formulation of tacrolimus designed for once-daily dosing. Phase 1 studies demonstrated greater bioavailability to twice-daily tacrolimus capsules and no new safety concerns. In this phase 2 study, adult stable kidney transplant patients on tacrolimus capsules (Prograf)
R S Bumbacea et al.
European annals of allergy and clinical immunology, 45(3), 109-110 (2013-07-19)
Type I hypersensitivity reactions have been described after solid organ transplantation despite T cell targeted immunosuppressive therapy. There are several reports of food allergy, asthma and eosinophilic colitis in pediatric transplant recipients under Tacrolimus immunosuppression, but not Cyclosporine A. We
[Successful effect of tacrolimus in a 5-year-old boy presenting with repeated episodes of non-herpetic acute limbic encephalitis].
K Kishi et al.
No to hattatsu = Brain and development, 45(2), 152-154 (2013-05-09)
Kensuke Kosugi et al.
Cranio : the journal of craniomandibular practice, 31(2), 140-150 (2013-06-26)
The authors performed a longitudinal study of the microstructural changes occurring in the mandibular condyle during osteoporosis using the findings obtained from micro-CT. The subjects used in this study were eight Sprague-Dawley rats. Among them, five were administered the immunosuppressant
Yingjing Wang et al.
Journal of biomedical nanotechnology, 9(2), 147-157 (2013-05-01)
As a traditional immunosuppressive drug, tacrolimus showed the potency in treating ulcerative colitis. In this study, a novel drug delivery vehicle achieved by self-assembly was applied to tacrolimus. During the preparation, amphiphilic copolymer MPEG-PCL was chosen to form the unique
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