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Safety Information

407709

Sigma-Aldrich

Insulin, Zinc, Human, Recombinant, P. pastoris

Synonym(s):

Insulin, Zinc, Human, Recombinant, P. pastoris

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About This Item

CAS Number:
11061-68-0
MDL number:
MFCD00131380
UNSPSC Code:
12352202
NACRES:
NA.77

sterility

non-sterile

Quality Level

200

form

solid

specific activity

≥25 IU/mg (dry basis)

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

impurities

<10 EU/mg Endotoxin (EU/mg protein)

color

white to off-white

solubility

0.01 M HCl: soluble

shipped in

wet ice

storage temp.

−20°C

InChI key

PBGKTOXHQIOBKM-FHFVDXKLSA-N

Related Categories

General description

Recombinant, human insulin (zinc) expressed in P. pastoris. A peptide anabolic hormone produced by pancreatic β-cells.
Recombinant, human insulin (zinc) expressed in P. pastoris. Peptide anabolic hormone produced by pancreatic β-cells. Increases the synthesis of protein, fat, glycogen, and substrate oxidation in mitochondria. Interacts with membrane insulin receptor to cause its biological actions.

Warning

Toxicity: Standard Handling (A)

Preparation Note

Insulin is practically insoluble from pH 4.5-7.0.

Reconstitution

Following reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 6 weeks at 4°C.

Other Notes

Mohan, C., et al. 1989. Curr. Topics Cell. Reg.30, 105.
Johnson, I.S. 1983. Science219, 632.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

nwg

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

US2407709-50:
407709-MG:
407709-1GM:
407709-0GM:
407709-50MG:

Certificates of Analysis (COA)

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Mohan Sreelekshmi et al.
Journal of biochemical and molecular toxicology, 35(6), 1-8 (2021-03-03)
Glucokinase (GK), a key regulator of hepatic glucose metabolism in the liver and glucose sensor and mediator in the secretion of insulin in the pancreas, is not studied in detail for its therapeutic application in diabetes. Herein, we study the
Kapil Manglani et al.
Cell biology international, 46(3), 488-497 (2021-12-06)
Role of CDK5 and its inhibition in various neuronal processes and functions are well established. However, role of CDK5 and its inhibition in neuronal insulin-signaling and-resistance is not yet explored. In the present study, we investigated the effect of CDK5
Medha Sharma et al.
Cell communication and signaling : CCS, 20(1), 179-179 (2022-11-16)
The aim of the present study was to determine the role of individual PHLPP isoforms in insulin signaling and insulin resistance in neuronal cells. PHLPP isoforms were either silenced or overexpressed individually, and the effects were observed on individual Akt
Yamini Yadav et al.
The FEBS journal, 289(23), 7561-7581 (2022-07-11)
PP2Cα is one of the newly identified isoforms of metal-dependent protein phosphatases (PPM). The role of this phosphatase in neuronal insulin signalling is completely unknown. In the present study, we show insulin-mediated rapid upregulation of a protein of the insulin
Kerrie A Morrison et al.
Scientific reports, 12(1), 3532-3532 (2022-03-05)
Extraction of integral membrane proteins with poly(styrene-co-maleic acid) provides a promising alternative to detergent extraction. A major advantage of extraction using copolymers rather than detergent is the retention of the lipid bilayer around the proteins. Here we report the first
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