5.04904

Ifenprodil Hemitartrate

• Synonym(s): Ifenprodil Hemitartrate, erythro-4-(2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl)phenol hemitartrate
• Empirical Formula (Hill Notation): C₂₁H₂₇NO₂ · 0.5C₄H₆O₆
• CAS Number: 23210-58-4
• Molecular Weight: 400.49
• MDL number: MFCD01529999
• UNSPSC Code: 12352200

Properties

• Assay: ≥99% (HPLC)
• Quality Level: 100
• form: solid
• potency: 0.15 μM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white
• solubility: DMSO: 100 mM
• storage temp.: 2-8°C
• InChI: 1S/2C21H27NO2.C4H6O6/c2*1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17;5-1(3(7)8)2(6)4(9)10/h2*2-10,16,18,21,23-24H,11-15H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t;;1-,2-/m..1/s1
• InChI key: DMPRDSPPYMZQBT-CEAXSRTFSA-N

Description

General description

A partial non-competitive antagonist highly selective for GluN1/N2B subtype NMDA receptors (IC₅₀ = 0.15 µM, maximal inhibition ˜90%) over other subtypes (IC₅₀ = 39, 29, 76 µM for GluN1/N2A, GluN1/N2C and GluN1/N2D subtype receptors, respectively). Frequently used in studies of various brain functions and disorders involving neural transmissions mediated by GluN1/N2B subtype NMDA receptors.

A partial non-competitive antagonist highly selective for GluN1/N2B subtype NMDA receptors (IC₅₀ = 0.15 µM, maximal inhibition ˜90%) over other subtypes (IC₅₀ = 39, 29, 76 µM for GluN1/N2A, GluN1/N2C and GluN1/N2D subtype receptors, respectively). Frequently used in studies of various brain functions and disorders involving neural transmissions mediated by GluN1/N2B subtype NMDA receptors.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Primary Target
GluN1/N2B subtype NMDA receptors

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Zhang, H., et al. 2013. Mol. Brain.6, 13.
Kishimoto, A., et al. 2013. J. Clin. Psychopharmacol.33, 143.
Bhat, J., et al. 2013. Mol. Pharmacol.83, 9.
Amico-Ruvio, S., et al. 2012. 82, 1074, 81.
Bhattacharya, P., et al. 2012. Med. Hypotheses.79, 516.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable