565730

Scriptaid

A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor.

• Synonym(s): Scriptaid, 6-(1,3-Dioxo-1 H,3 H-benzo[ de]isoquinolin-2-yl)-hexanoic Acid Hydroxyamide, CGK1026, HDAC Inhibitor XIII, 6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-hexanoic Acid Hydroxyamide, CGK1026, HDAC Inhibitor XIII
• Empirical Formula (Hill Notation): C₁₈H₁₈N₂O₄
• CAS Number: 287383-59-9
• Molecular Weight: 326.35
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: DMSO: 4 mg/mL
• shipped in: ambient
• storage temp.: −20°C
• InChI: 1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)
• InChI key: JTDYUFSDZATMKU-UHFFFAOYSA-N

Description

General description

A relatively non-toxic hydroxamic acid-containing histone deacetylase (HDAC) inhibitor. Facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient reporter assays in a concentration-dependent manner. Useful agent for transfection assays in reporter systems due to the lack of interference with the ability of reporter construct to measure positive activation of transcription factor in response to signal transduction stimulus. It causes over 100-fold increase in histone acetylation in PANC-1 cells at 2 µg/ml (6 µM). Reported to derepress hTERT by inhibiting the recruitment of HDAC into E2F-pocket protein complexes assembled on the hTERT promoter.

A relatively non-toxic, cell-permeable hydroxamic acid-containing histone deacetylase (HDAC) inhibitor. Facilitates transcriptional activation (TGFβ/Smad4) in both stable and transient receptor assays in a concentration-dependent manner. At ~2 µg/ml (6-8 µM) concentrations, results in a greater than 100-fold increase in histone acetylation in PANC-1 cells. Reported to derepress hTERT by inhibiting the recruitment of HDAC into E2F-pocket protein complexes assembled on the hTERT promoter.

Biochem/physiol Actions

Cell permeable: yes

Primary Target
HDAC

Product does not compete with ATP.

Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Won, J., et al. 2004. Proc. Natl. Acad. Sci. USA101, 11328.
Su, G.H., et al. 2000. Cancer Res.60, 3137.

Legal Information

Sold under license of U.S. Patent 6,544,957.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable