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70856

Millipore

RNase A Solution

Convenient solution for selective degradation of RNA

Synonym(s):

RNase A Enzyme

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.54

form

solution

manufacturer/tradename

Novagen®

storage condition

OK to freeze

concentration

10 mg/mL

technique(s)

DNA purification: suitable

shipped in

ambient

storage temp.

10-30°C

General description

RNase A Solution is a convenient alternative to powdered RNase A. It is a highly purified preparation of bovine pancreatic ribonuclease A suitable for use in selective removal of RNA. It has been pretreated to remove DNase I and is suitable to remove RNA contamination during plasmid and genomic DNA purification procedures. Supplied at a concentration of 10 mg/ml in 10 mM Tris-HCl, 1 mM EDTA, 50% glycerol, pH 7.5.

Application

RNase A Solution has been used:
  • in cell cycle profiling of embryonic mouse neuroectodermal cells (NE-4C)
  • in the digestion of RNA for extraction of DNA from human osteosarcoma cell lines for chromatin immunoprecipitation (ChIP) assays
  • to treat control adult and embryonic thymi cells during staining
  • to remove RNA from affibody–mRNA fusion clones before clone screening

Biochem/physiol Actions

RNaseA is an endoribonuclease that catalyzes the degradation of phosphodiester linkages with a pyrimidine base at the 3′ -position on single-stranded RNA via, transphosphorylation and hydrolysis mechanism.

Warning

Toxicity: Standard Handling (A)

Legal Information

NOVAGEN is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H334

Precautionary Statements

P261 - P284 - P501

Hazard Classifications

Resp. Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

70856-ML:
70856-3:
70856-1ML:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Neurotrophic properties and the de novo peptide sequencing of edible bird's nest extracts
Yew M Y, et al.
Food Bioscience, 32, 100466-100466 (2019)
Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth
Jennifer E C, et al.
Nature Communications (2019)
Jiajun Zhang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 26(11), 2681-2692 (2020-01-16)
Malignancy of cancer cells depends on the active transcription of tumor-associated genes. Recently, unique clusters of transcriptional enhancers, termed super-enhancers, have been reported to drive the expression of genes that define cell identity. In this study, we characterized specific super-enhancer-associated

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