8.51085

COMU

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

• Synonym(s): COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholino)] uronium hexafluorophosphate
• Empirical Formula (Hill Notation): C₁₂H₁₉F₆N₄O₄P
• CAS Number: 1075198-30-9
• Molecular Weight: 428.27
• MDL number: MFCD11975052
• UNSPSC Code: 12352107
• NACRES: NA.22

Properties

• Product Name: COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylaminomorpholino)] uronium hexafluorophosphate Novabiochem^®
• Quality Level: 300
• product line: Novabiochem^®
• Assay: ≥99.0% (HPLC)
• form: powder
• reaction suitability: reaction type: Coupling Reactions
• manufacturer/tradename: Novabiochem^®
• mp: >140 °C
• application(s): peptide synthesis
• storage temp.: 15-25°C
• SMILES string: F[P-](F)(F)(F)(F)F.N1(CCOCC1)C(=[O+]\N=C(/C(=O)OCC)\C#N)N(C)C
• InChI: 1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;
• InChI key: GPDHNZNLPKYHCN-DZOOLQPHSA-N

Description

General description

COMU is a novel reagent which mediates coupling reactions with efficiencies comparable to HATU ^[1,2].It has higher solubility than HATU and HBTU. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Recently, the application of COMU in the preparation of esters has been demonstrated ^[3].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

^[1] A. El-Faham, et al. (2009) Chem. Eur. J., 15, 9404.
^[2] A. El-Faham & F. Albericio (2010) J. Pept. Sci., 16, 6.
^[3] Jean-d′Amour, et al. (2011) Org. Lett., 13, 2988.

Application

• Re-evaluating the stability of COMU in different solvents: This study highlights the robust stability and effectiveness of COMU, promoting its use in various peptide synthesis scenarios, enhancing both scalability and environmental friendliness (Kumar et al., 2017).

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (10% in acetonitrile): clear

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable