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11126

Sigma-Aldrich

Potassium antimonyl tartrate trihydrate

puriss., meets analytical specification of USP, 99.0-103.0%, powder

Synonym(s):

Antimony potassium tartrate trihydrate, Tartar emetic

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About This Item

Empirical Formula (Hill Notation):
C8H4K2O12Sb2 · 3H2O
CAS Number:
28300-74-5
Molecular Weight:
667.87
EC Number:
234-293-3
MDL number:
MFCD00167056
UNSPSC Code:
12352100
PubChem Substance ID:
57646885
NACRES:
NA.21

grade

puriss.

Quality Level

200

Assay

99.0-103.0%

form

powder

quality

meets analytical specification of USP

impurities

≤0.02 mmol/g free acid
≤0.02 mmol/g free alkali

loss

≤2.7% loss on drying, 105 °C

mp

≥300 °C (lit.)

cation traces

As: ≤150 mg/kg
Pb: ≤20 mg/kg

SMILES string

O.O.O.[K+].[K+].O=C1O[Sb-]23OC1C4O[Sb-]5(OC(C(O2)C(=O)O3)C(=O)O5)OC4=O

InChI

1S/2C4H4O6.2K.3H2O.2Sb/c2*5-1(3(7)8)2(6)4(9)10;;;;;;;/h2*1-2H,(H,7,8)(H,9,10);;;3*1H2;;/q2*-2;2*+1;;;;2*+3/p-4

InChI key

WBTCZEPSIIFINA-UHFFFAOYSA-J

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General description

Potassium antimonyl tartrate trihydrate is a trivalent antimonial compound. It has been reported to be more toxic than pentavalent antimony (Pentostam) against Leishmania species. Its crystal structure has been investigated by the three-dimensional X-ray and white radiation neutron diffraction techniques. It crystallizes in space group C2221. Unit cell dimensions reported were: a = 11.192(2), b = 11.696(3), and c = 25.932(5)Å.

Application

Potassium antimonyl tartrate trihydrate was employed as an Sb(III)-containing drug to investigate its ability to induce cell death associated with DNA fragmentation in axenic amastigotes of Leishmania infantum†
It may also be used as a standard solution to determine the metalloid concentration such as Sb(III) and Sb(V) in surface soil, using high performance liquid chromatography coupled to inductively coupled plasma-mass spectrometry (HPLC-ICP-MS).

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H301,H315,H317,H332,H411

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

PRTR

Class I Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

11126-VAR:
11126-1.5KG:
11126-1KG:4548173373515
11126-BULK:
11126-6X1KG:
11126-6X250G:
11126-250G:4548173373522

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL6284
BCCM2223
BCCK0006
BCCG6808
BCCG6346

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"A study of antimony complexed to soil-derived humic acids and inorganic antimony species along a Massachusetts highway"
Ceriotti G and Amarasiriwardena D
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 91(01), 85-93 (2009)
D Sereno et al.
Antimicrobial agents and chemotherapy, 45(7), 2064-2069 (2001-06-16)
The basic treatment of leishmaniasis consists in the administration of pentavalent antimonials. The mechanisms that contribute to pentavalent antimonial toxicity against the intracellular stage of the parasite (i.e., amastigote) are still unknown. In this study, the combined use of several
D Sereno et al.
Antimicrobial agents and chemotherapy, 41(5), 972-976 (1997-05-01)
Using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide microassay, previously described as a means of quantifying Leishmania amazonensis in vitro at the amastigote stage (D. Sereno and J. L. Lemesre, Parisitol. Res., in press), we have compared the activities of seven drugs, including those
D Sereno et al.
Antimicrobial agents and chemotherapy, 42(12), 3097-3102 (1998-12-03)
The mechanism(s) of activity of pentavalent antimony [Sb(V)] is poorly understood. In a recent study, we have shown that potassium antimonyl tartrate, a trivalent antimonial [Sb(III)], was substantially more potent than Sb(V) against both promastigotes and axenically grown amastigotes of
X-ray and white radiation neutron diffraction studies of optically active potassium antimony tartrate, K2Sb2(dC4H2O6)2? 3H2O (tarter emetic).
Gress ME and Jacobson RA.
Inorgorganica Chimica Acta, 8, 209-217 (1974)
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