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Safety Information

134236

Sigma-Aldrich

Morpholine

ReagentPlus®, ≥99%

Synonym(s):

Tetrahydro-1,4-oxazine

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About This Item

Empirical Formula (Hill Notation):
C4H9NO
CAS Number:
110-91-8
Molecular Weight:
87.12
Beilstein:
102549
EC Number:
203-815-1
MDL number:
MFCD00005972
UNSPSC Code:
12352100
eCl@ss:
39162409
PubChem Substance ID:
24848140
NACRES:
NA.21

vapor density

3 (vs air)

Quality Level

200

vapor pressure

31 mmHg ( 38 °C)
7 mmHg ( 20 °C)

product line

ReagentPlus®

Assay

≥99%

form

liquid

autoignition temp.

590 °F

expl. lim.

10.8 %

refractive index

n20/D 1.454 (lit.)

bp

129 °C (lit.)

mp

−7-−5 °C (lit.)

density

0.996 g/mL at 25 °C (lit.)

functional group

ether

SMILES string

C1COCCN1

InChI

1S/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H2

InChI key

YNAVUWVOSKDBBP-UHFFFAOYSA-N

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General description

Morpholine can be obtained, via degradation of N-methylmorpholine N-oxide (NMMO) during fiber production.

Morpholine is a cyclic amine that serves as a solvent, corrosion inhibitor, and chemical intermediate.

Application

Morpholine can be used as a buffer component in the separation of peptides and pathogenic lipopolysaccharides during on-line chromatographic preconcentration coupled to capillary zone electrophoresis–electrospray mass spectrometry (cPC–CZE–ES-MS) analysis from colony isolates.

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Repr. 2 - Skin Corr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

87.8 °F - closed cup

Flash Point(C)

31 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

FSL

Group 4: Flammable liquids
Type 2 petroleums
Hazardous rank III
Water soluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

134236-2L:
134236-100ML:4548173928678
134236-BULK:
134236-2.5L:
134236-500ML:4548173928685
134236-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
MKCT3348
STBK6914
STBK6296
STBK8032
MKCR7420

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Flow injection analysis with amperometric detection for morpholine determination in corrosion inhibitors
Oliveira SMD, et al.
Journal of the Brazilian Chemical Society, 25, 1399-1406 (2014)
"Determination of morpholine and N-methylmorpholine formed as degradation products in cellulose fiber production by capillary isotachophoresis"
Widhalm A and Kenndler E
Analytical Chemistry, 63(06), 645-648 (1991)
"Development of an on-line preconcentration method for the analysis of pathogenic lipopolysaccharides using capillary electrophoresis?electrospray mass spectrometry: Application to small colony isolates1NRCC No.: 39585.1"
Li.J, et al.
Journal of Chromatography A, 817(01), 325-336 (1998)
M H Jayan S Karunarathna et al.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 20(2), 255-263 (2021-03-16)
The photochemistry of Fe(III) coordinated to natural uronate-containing polysaccharides has been investigated quantitatively in aqueous solution. It is demonstrated that the photoreduction of the coordinated Fe(III) to Fe(II) and oxidative decarboxylation occurs in a variety of uronate-containing polysaccharides. The photochemistry
Shi-Kai Xiang et al.
Chemical communications (Cambridge, England), 47(28), 8097-8099 (2011-06-21)
Organocatalytic direct C3 alkenylation of indoles has been developed. Simple and readily available morpholine trifluoroacetic acid salt is employed as an efficient catalyst in this oxidative dehydrogenative reaction. Simplicity and practicality constitute the most attractive advantages of this reaction.
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