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Safety Information

49702

Supelco

Carnosol

analytical standard

Synonym(s):

Picrosalvin

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About This Item

Empirical Formula (Hill Notation):
C20H26O4
CAS Number:
5957-80-2
Molecular Weight:
330.42
MDL number:
MFCD02752467
UNSPSC Code:
85151701
PubChem Substance ID:
329757507
NACRES:
NA.24

biological source

Rosemarinus officinalis L. leaves

Quality Level

100

grade

analytical standard

Assay

≥98.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

food and beverages

format

neat

storage temp.

−20°C

SMILES string

CC(C)c1cc2[C@@H]3C[C@H]4C(C)(C)CCC[C@]4(C(=O)O3)c2c(O)c1O

InChI

1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1

InChI key

XUSYGBPHQBWGAD-PJSUUKDQSA-N

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General description

Carnosol is a naturally occurring phyto polyphenolor phenolic diterpene, found in rosemary, which can show a broad spectrum of applications as a an antioxidant, anticancer agent and anti-inflammatory agent.
Carnosol is one of the phenolic antioxidants present in extracts of the herb rosemary (Rosmarinus officinalis). Carnosol inhibits the formation of tumors derived using irritants such as TPA and DMBA in murine models of carcinogenesis.The effective dose reported is 1-10 μM topically or 6 μg/ml when added to supernatants of cultured cells.Addition of rosemary extracts to the diet as a 1% supplement by weight was also found to decrease the frequency of DMBA-DNA adducts.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

A phenolic diterpene with antioxidant and anticarcinogenic activities.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

This compound is commonly found in plants of the genus: salvia

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317

Precautionary Statements

P280 - P302 + P352

Hazard Classifications

Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

49702-10MG:
49702-BULK:
49702-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM3177
BCCL2882
BCCJ9703
BCCH4711
BCCG9960

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Carnosol: a promising anti-cancer and anti-inflammatory agent
Johnson.JJ
Cancer Letters, 305, 1-7 (2011)
Chien-chung Chen et al.
Acta pharmacologica Sinica, 32(1), 62-69 (2010-12-15)
To explore whether glutathione (GSH) increased through Nrf-2 activation is involved in the cytoprotective effects of carnosol in HepG2 cells. Human hepatoma cell line HepG2 were exposed to rosemarry essential oil or carnosol. Cell viability was measured using an Alamar
Pi-wen Zhao et al.
Biological & pharmaceutical bulletin, 35(11), 1947-1955 (2012-09-14)
Antioxidant action is critical for maintaining the normal cardiovascular function and vascular endothelial cell is an important target of estrogen action through estrogen receptor (ER) pathway. This study is carried out to explore the antioxidant effect of carnosol in bovine
Jeremy J Johnson et al.
Cancer prevention research (Philadelphia, Pa.), 3(9), 1112-1123 (2010-08-26)
Emerging data are suggesting that estrogens, in addition to androgens, may also be contributing to the development of prostate cancer (PCa). In view of this notion, agents that target estrogens, in addition to androgens, may be a novel approach for
Shiu-Chen Huang et al.
Biochemical pharmacology, 69(2), 221-232 (2005-01-04)
Carnosol, a constant constituent of Rosmarinus officinalis extracts, is a phenolic diterpene shown to have antioxidant and anticarcinogen properties. In our studies, carnosol inhibited the invasion of highly metastatic mouse melanoma B16/F10 cells in vitro. First, the antimetastatic potentials of
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