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Safety Information

88580

Sigma-Aldrich

Phenothiazine

purum, ≥98.0% (GC)

Synonym(s):

PTZ, 10H-Phenothiazine

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About This Item

Empirical Formula (Hill Notation):
C12H9NS
CAS Number:
Molecular Weight:
199.27
Beilstein:
143237
EC Number:
MDL number:
UNSPSC Code:
12352103
PubChem Substance ID:
NACRES:
NA.23

grade

purum

Quality Level

Assay

≥98.0% (GC)

form

pellets

bp

371 °C (lit.)

mp

182-187 °C (lit.)
183-187 °C

SMILES string

N1c2ccccc2Sc3ccccc13

InChI

1S/C12H9NS/c1-3-7-11-9(5-1)13-10-6-2-4-8-12(10)14-11/h1-8,13H

InChI key

WJFKNYWRSNBZNX-UHFFFAOYSA-N

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General description

The structure of phenothiazine is rigid, being tricyclic. It is known to alter dopamine (3,4-dihydroxyphenethylamine). Its use as an electron donor is based on its unique hole transporting ability, electron releasing nitrogen and sulfur heteroatoms and its non-planar structure leading to lower molecular aggregation.

Application

Phenothiazine finds uses in metal free organic dye sensitizers, dyes and antioxidants.

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 - STOT RE 2 Oral

Target Organs

Blood

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class II Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

88580-1KG:4548173966021
88580-VAR:
88580-250G:4548173966038
88580-50G:4548173966045
88580-BULK:


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Acridine and phenothiazine derivatives as pharmacotherapeutics for prion disease
Carsten K, et al
Proceedings of the National Academy of Sciences of the USA, 98(17), 9834-9841 (2001)
A S Horn et al.
Proceedings of the National Academy of Sciences of the United States of America, 68(10), 2325-2328 (1971-10-01)
Phenothiazines and butyrophenones are known to alter dopamine (3,4-dihydroxyphenethylamine) metabolism in the brain in a fashion suggesting that they may block dopamine receptors. We observed, using Dreiding molecular models, that dopamine in its solid-state conformation is superimposable upon a portion
Photodegradation of trimeprazine triggered by self-photogenerated singlet molecular oxygen
Waseem A, et al
Journal of Saudi Chemical Society (2012)
Asif M, et al
Arabian Journal of Chemistry null
Gabriela B Rodrigues et al.
Journal of photochemistry and photobiology. B, Biology, 116, 89-94 (2012-09-18)
Photodynamic antimicrobial chemotherapy (PACT) is a promising alternative to conventional chemotherapy that can be used to treat localized mycosis. The development of PACT depends on identifying effective and selective PS for the different pathogenic species. The in vitro susceptibilities of

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