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Safety Information

P7003

Supelco

Piperazine hexahydrate

analytical standard

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About This Item

Empirical Formula (Hill Notation):
C4H10N2 · 6H2O
CAS Number:
142-63-2
Molecular Weight:
194.23
Beilstein:
4455527
EC Number:
203-808-3
MDL number:
MFCD00149389
UNSPSC Code:
41116107
PubChem Substance ID:
329820258
NACRES:
NA.24

grade

analytical standard

Quality Level

200

vapor pressure

0.8 mmHg ( 20 °C)

Assay

≥99% (TLC)

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

bp

145-156 °C (lit.)

mp

42-44 °C (lit.)

application(s)

forensics and toxicology
pharmaceutical (small molecule)

format

neat

SMILES string

[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].C1CNCCN1

InChI

1S/C4H10N2.6H2O/c1-2-6-4-3-5-1;;;;;;/h5-6H,1-4H2;6*1H2

InChI key

AVRVZRUEXIEGMP-UHFFFAOYSA-N

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General description

Piperazine hexahydrate may be used as a standard for the determination of piperazine in pharmaceutical preparations using colorimetric technique.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Pictograms

Health hazardCorrosion
GHS08,GHS05

Signal Word

Danger

Hazard Statements

H314,H317,H334,H361fd

Hazard Classifications

Repr. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

190.4 °F - closed cup

Flash Point(C)

88 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

P7003-200G:
P7003-1KG:
P7003-BULK:
P7003-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
0000322048
0000322048
0000406827
0000404013
0000383315

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Colorimetric determination of piperazine in pharmaceutical formulations
Dessouky M Y and Ismaiel A S.
Analyst, 99(1181), 482-486 (1974)
Juneha Bak et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 36(10), 1269-1274 (2020-06-23)
Sulfated saccharides exhibit diverse physiological activities, but a lack of any convenient assay hinders their evaluation. Herein, an assay for the analysis of sulfated saccharides is described using 1H nuclear magnetic resonance (NMR) spectroscopy by employing ligands that can form
P Krishnan et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 102, 379-385 (2012-12-12)
Monohydrate piperazine hydrogen phosphate (MPHP), a semi organic nonlinear optical material has been synthesized and single crystals were grown from aqueous solution by slow evaporation technique. Single crystal X-ray diffraction study on grown crystal reveals that they belong to monoclinic
Yuji Nakamura et al.
Bioorganic & medicinal chemistry letters, 22(14), 4561-4566 (2012-06-26)
Introduction of the 2,2-dimethyl-4-phenylpiperazin-5-one scaffold into the P(3)-P(1) portion of the (2S,4S,5S)-5-amino-6-dialkylamino-4-hydroxy-2-isopropylhexanamide backbone dramatically increased the renin inhibitory activity without using the interaction to the S(3)(sp) pocket. Compound 31 exhibited >10,000-fold selectivity over other human proteases, and 18.5% oral bioavailability
Carl Cheadle et al.
Dalton transactions (Cambridge, England : 2003), 42(14), 4931-4946 (2013-02-07)
A new multidentate bifunctional organic ligand – di-N,N′-(2-cyano-2-oximinoacetyl)piperazine – was synthesized in high yield using a two-step procedure carried out under ambient conditions. At first, the reaction of piperazine and neat methylcyanoacetate led to the di-N,N′-(cyanoacetyl)piperazine (1), which then was
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