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360481

Sigma-Aldrich

1,4-Dioxane

ACS reagent, ≥99.0%, contains ≤25 ppm BHT as stabilizer

Synonym(s):

Diethylene oxide, Dioxane

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About This Item

Empirical Formula (Hill Notation):
C4H8O2
CAS Number:
123-91-1
Molecular Weight:
88.11
Beilstein:
102551
EC Number:
204-661-8
MDL number:
MFCD00006571
UNSPSC Code:
12352005
PubChem Substance ID:
329755260
NACRES:
NA.21

grade

ACS reagent

Quality Level

200

vapor density

3 (vs air)

vapor pressure

27 mmHg ( 20 °C)
40 mmHg ( 25 °C)

Assay

≥99.0%

form

liquid

autoignition temp.

356 °F

contains

≤25 ppm BHT as stabilizer

expl. lim.

22 %

impurities

≤0.0016 meq/g Titr. acid
≤0.005% Peroxide (as H2O2)
≤0.01% Carbonyl (as HCHO)
≤0.05% water

evapn. residue

≤0.005%

color

APHA: ≤20

refractive index

n20/D 1.422 (lit.)

pH

6.0-8 (20 °C, 500 g/L)

bp

100-102 °C (lit.)

mp

10-12 °C (lit.)

transition temp

freezing point ≥11.0

density

1.034 g/mL at 25 °C (lit.)

SMILES string

C1COCCO1

InChI

1S/C4H8O2/c1-2-6-4-3-5-1/h1-4H2

InChI key

RYHBNJHYFVUHQT-UHFFFAOYSA-N

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General description

1,4-Dioxane is a heterocyclic organic compound that is commonly used as a solvent in several chemical reactions. It is also used as a stabilizer in chlorinated solvents.

Application

1,4-Dioxane can be used as:      
  • A solvent in the N-methylation of amines by reductive functionalization of CO2 in the presence of NaBH4 as the reducing reagent.      
  • An additive to synthesize 3-hydroxylisoindolin-1-ones via hydroxylhydrative aza-cyclization of 2-alkynylbenzamide.

A mixture of 1,4-dioxane/ethanol/formic acid solvent system can be used in the depolymerization of lignin to synthesize value-added phenolic monomers.

Signal Word

Danger

Hazard Statements

H225,H319,H335,H350

Hazard Classifications

Carc. 1B - Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3

Target Organs

Respiratory system

Supplementary Hazards

EUH019,EUH066

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

51.8 °F - closed cup

Flash Point(C)

11 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PRTR

Class I Designated Chemical Substances

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water soluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

360481-CH:
360481-6X500ML:4548173139548
360481-2.5L:
360481-2L:4548173139517
360481-1L:4548173139494
360481-4X2.5L:
360481-4L:
360481-4X2L:4548173261959
360481-3L:4548173261942
360481-500ML:4548173139531
360481-18L:4548173261935
360481-18L-CS:
360481-BULK:
360481-4X4L:4548173139524
360481-20L:4548173139500
360481-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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1,4-Dioxane solution NMR reference standard, 40% in benzene-d6 (99.6 atom % D), chromium(III) acetylacetonate 5 mg/mL, NMR tube size 3 mm × 8 in.

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612073

1,4-Dioxane solution

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