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571261

Sigma-Aldrich

Piperidine

biotech. grade, ≥99.5%

Synonym(s):

Hexahydropyridine

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About This Item

Empirical Formula (Hill Notation):
C5H11N
CAS Number:
110-89-4
Molecular Weight:
85.15
Beilstein:
102438
EC Number:
203-813-0
MDL number:
MFCD00005979
UNSPSC Code:
12352005
PubChem Substance ID:
329758271
NACRES:
NA.21
grade:
biotech. grade
Assay:
≥99.5%
technique(s):
DNA sequencing: suitable
bp:
106 °C (lit.)
106 °C
vapor pressure:
23 mmHg ( 20 °C)

grade

biotech. grade

Quality Level

100

vapor density

3 (vs air)

vapor pressure

23 mmHg ( 20 °C)

Assay

≥99.5%

form

liquid

technique(s)

DNA sequencing: suitable

impurities

<0.3% water

refractive index

n20/D 1.452 (lit.)

bp

106 °C (lit.)
106 °C

mp

−13 °C (lit.)

solubility

organic solvents: soluble(lit.)
water: miscible(lit.)

density

0.862 g/mL at 20 °C (lit.)

λ

1 cm path, H2O reference

UV absorption

λ: 290 Amax: <1.000
λ: 370 Amax: <0.050

SMILES string

C1CCNCC1

InChI

1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2

InChI key

NQRYJNQNLNOLGT-UHFFFAOYSA-N

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General description

Piperidine, a heterocyclic cyclohexane is a volatile secondary amine. Maxam-Gilbert chemical method, a DNA sequencing technology employs piperidine to rupture DNA strands at damaged base site. Its crystal structure analyzed at 150K shows hydrogen bonding between NH groups. Piperidine ring forms a part of many naturally occuring alkaloids. It is prepared on an industrial scale by the hydrogenation of pyridine in the presence of nickel catalyst. The 1H NMR spectrum of piperidine has been recorded.

Application

Fits Applied Biosystems 431 and 433A peptide synthesizers.
Piperidine has been used in combination with DMF (dimethylformamide) for the removal of Fmoc (fluorenylmethyloxycarbonyl) group from the N-terminal amino group during peptide synthesis.

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

60.8 °F - closed cup

Flash Point(C)

16 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 1 petroleums
Hazardous rank II
Water soluble liquid

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

571261-200ML:
571261-BULK:
571261-450ML:
571261-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
SHBM2720
SHBH5650V
SHBH5309V
BCBH1918V
1450489V

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Peptide Synthesis.
Miao Z and Cheng Z
Bio-protocol, 2(14) (2012)
W B Mattes et al.
Biochimica et biophysica acta, 868(1), 71-76 (1986-10-16)
The volatile, secondary amine piperidine is used in the Maxam-Gilbert chemical method of DNA sequencing to create strand breaks in DNA at sites of damaged bases. As such it is often used in generalized studies of DNA damage to identify
Andrew Parkin et al.
Acta crystallographica. Section B, Structural science, 60(Pt 2), 219-227 (2004-03-16)
The crystal structures of piperazine, piperidine and morpholine have been determined at 150 K. All three structures are characterized by the formation of NH...N hydrogen-bonded chains. In piperazine these are linked to form sheets, but the chains are shifted so
Total synthesis of (-)-kopsinine by an asymmetric one-pot [n+2+3] cyclization.
Shingo Harada et al.
Chemistry, an Asian journal, 7(10), 2196-2198 (2012-08-22)
J Phillip Turner et al.
ACS chemical neuroscience, 5(7), 552-558 (2014-04-03)
Alzheimer's disease (AD) is the most common form of dementia and the sixth leading cause of death in the United States. Plaques composed of aggregated amyloid-beta protein (Aβ) accumulate between the neural cells in the brain and are associated with
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