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Safety Information

137272

SAFC

Guanidine hydrochloride

EMPROVE® EVOLVE

Pharma Manufacturing

Synonym(s):

Guanidine hydrochloride, Aminoformamidine hydrochloride, Aminomethanamidine hydrochloride, Guanidinium chloride

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About This Item

Linear Formula:
NH2C(=NH)NH2 · HCl
CAS Number:
50-01-1
Molecular Weight:
95.53
Beilstein:
3591990
MDL number:
MFCD00013026
UNSPSC Code:
12352107

biological source

synthetic

Quality Level

400

product line

EMPROVE® EVOLVE

form

powder

impurities

Endotoxin, microbial, and trace metals; tested

pH

(25 °C, 4.6 - 6/573 g/L)

mp

180-185 °C (lit.)
180-185 °C (lit.)

solubility

water: 6 M at 20 °C, clear, colorless

density

1.3 g/cm3 (lit.)
1.3 g/cm3 (lit.)

suitability

suitable for manufacturing use

storage temp.

2-30°C

SMILES string

Cl[H].NC(N)=N

InChI

1S/CH5N3.ClH/c2-1(3)4;/h(H5,2,3,4);1H

InChI key

PJJJBBJSCAKJQF-UHFFFAOYSA-N

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General description

Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

Application

Strong chaotropic agent useful for the denaturation and subsequent refolding of proteins. This strong denaturant can solubilize insoluble or denatured proteins such as inclusion bodies. This can be used as the first step in refolding proteins or enzymes into their active form. Urea and dithiothreitol (DTT) may also be necessary.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302 + H332,H315,H319

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

1372729050:
1372729999:
1372720003:
1372720000:
1372729025:
1372720100-KC:
1372720100:
1372722000:
1372725000:

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Certificates of Analysis (COA)

Lot/Batch Number
0000411073
0000411073
0000391449
0000391449
0000418401

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