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94742

Sigma-Aldrich

Vanadyl ribonucleoside complexes solution

BioReagent, for molecular biology, 200 mM

Synonym(s):

Ribonucleoside vanadyl complexes

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.52

grade

for molecular biology

Quality Level

100

product line

BioReagent

form

liquid

concentration

200 mM

impurities

oxovanadium V

suitability

in accordance for ribonuclease inhibition test

shipped in

dry ice

storage temp.

−20°C

General description

Vanadyl ribonucleoside complexes are low molecular weight inhibitors of ribonucleases.
Vanadyl ribonucleoside complexes solution is an inhibitor for ribonuclease (RNase). Use of vanadyl ribonucleoside complexes exhibits protection from degradation by RNase in tissue, genomic, RNA and protein samples.

Application

Vanadyl ribonucleoside complexes (VDR) are transition state analogs that bind to active sites of many RNases, inhibiting their activity. Because the RNases are not covalently modified by the complexes, VDR must be used at every stage of RNA extraction and purification. However, VDR also inhibit RNA polymerases and in vitro translation and therefore must be removed from final preparation of RNA.
Vanadyl ribonucleoside complexes solution has been used:
  • as a component of polysome lysis buffer and fluorescence in situ hybridization (FISH) buffer
  • as a RNase inhibitor for the isolation of endogenous YTH domain-containing 2 protein (YTHDC2) from mouse testes

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

94742-VAR:
94742-BULK:
94742-10ML:
94742-1ML:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCH1185
BCCB5610
BCBQ8665V
BCBF9912V
BCBF9912

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Regulation of m 6 A Transcripts by the 3?? 5? RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline
Wojtas MN, et al.
Molecular Cell, 68(2), 374-387 (2017)
Immunoprecipitation of mRNA-protein complexes
Peritz T, et al.
Nature Protocols, 1(2), 577-577 (2006)
Single-molecule Fluorescence in situ Hybridization (smFISH) for RNA Detection in Adherent Animal Cells
Haimovich G and Gerst JE
Proceedings of the National Academy of Sciences of the USA, 8(21) (2018)
Wei Wang et al.
Nucleic acids research, 36(15), 4913-4928 (2008-07-26)
The mechanisms of influenza A virus mRNA intracellular transport are still not clearly understood. Here, we visualized the distribution and transport of influenza A virus mRNA in living cells using molecular beacon (MB) technology. Confocal-FRAP measurements determined that the transport
CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development
Hupalowska A, et al.
Cell, 175(7), 1902-1916 (2018)
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