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Safety Information

A5665

Sigma-Aldrich

Adenine

BioReagent, suitable for plant cell culture, ≥99%

Synonym(s):

6-Aminopurine, Vitamin B4

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About This Item

Empirical Formula (Hill Notation):
C5H5N5
CAS Number:
73-24-5
Molecular Weight:
135.13
Beilstein:
5777
EC Number:
200-796-1
MDL number:
MFCD00041790
UNSPSC Code:
10171502
PubChem Substance ID:
24891010
NACRES:
NA.72

product line

BioReagent

Quality Level

200

Assay

≥99%

form

powder

mol wt

Mw 135.13 g/mol

technique(s)

cell culture | plant: suitable

color

white to off-white

mp

>360 °C (lit.)

solubility

0.5 M HCl: soluble 20 mg/mL, clear to slightly hazy, colorless to faintly yellow

application(s)

agriculture

SMILES string

Nc1ncnc2[nH]cnc12

InChI

1S/C5H5N5/c6-4-3-5(9-1-7-3)10-2-8-4/h1-2H,(H3,6,7,8,9,10)

InChI key

GFFGJBXGBJISGV-UHFFFAOYSA-N

Gene Information

human ... AKT1(207) , GSK3B(2932) , LCK(3932) , MAP3K1(4214) , MAPK14(1432) , MAPK8(5599) , MAPK9(5601) , MAPKAPK2(9261) , PRKACA(5566) , PRKCA(5578) , RAF1(5894) , ROCK2(9475)
mouse ... Mapk1(26413)
rat ... Camk2a(25400) , Mapk10(25272)

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General description

Adenine (Ade) is a purine base, which is present in nucleic acids. It binds with ribose to form nucleoside adenosine (A) and attach to deoxyribose to form nucleoside deoxyadenosine (dA).

Application

Adenine has been used in yeast extract supplemented (YES) broth and yeast nitrogen base glutamate (YNG)l media.
Adenine may be used as a plant cell culture additive. Adenine Sulphate (25mg/L) in the culture media such as Murashige & Skoog media improves the frequency of multiple shoot production and recovered the chlorotic symptoms of the leaves.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A5665-500G:
A5665-100G:
A5665-25G:
A5665-VAR:
A5665-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000343347
0000343346
SLCN1836
SLCJ8390
SLCB0010

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Adenine
Encyclopedia of Genetics (2001)
Single-step marker switching in Schizosaccharomyces pombe using a lithium acetate transformation protocol
Brown S D and Lorenz A
Bio-protocol, 6(24) (2016)
Didier Wion et al.
Nature reviews. Microbiology, 4(3), 183-192 (2006-02-21)
N(6)-methyl-adenine is found in the genomes of bacteria, archaea, protists and fungi. Most bacterial DNA adenine methyltransferases are part of restriction-modification systems. Certain groups of Proteobacteria also harbour solitary DNA adenine methyltransferases that provide signals for DNA-protein interactions. In gamma-proteobacteria
Georg Behrens et al.
AIDS patient care and STDs, 28(4), 168-175 (2014-03-26)
The once daily, single-tablet regimen (STR) combining rilpivirine (RPV), emtricitabine (FTC), and tenofovir disoproxil fumarate (TDF) provides a simplified treatment option for antiretroviral therapy (ART)-naïve patients with baseline HIV-1 RNA (BLVL) of ≤100,000 copies/mL. The aim of this analysis is
Jennifer B Kozdon et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(48), E4658-E4667 (2013-11-13)
The Caulobacter DNA methyltransferase CcrM is one of five master cell-cycle regulators. CcrM is transiently present near the end of DNA replication when it rapidly methylates the adenine in hemimethylated GANTC sequences. The timing of transcription of two master regulator
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