A8937

Adenosine 5′-triphosphate dipotassium salt hydrate

from microbial, ≥92% (HPLC)

• Synonym(s): ATP, 5′-ATP-K₂
• Empirical Formula (Hill Notation): C₁₀H₁₄K₂N₅O₁₃P₃ · xH₂O
• CAS Number: 42373-41-1
• Molecular Weight: 583.36 (anhydrous basis)
• MDL number: MFCD00084672
• UNSPSC Code: 41106305
• eCl@ss: 32160414
• PubChem Substance ID: 24891383
• NACRES: NA.51

Properties

• biological source: microbial
• Quality Level: 200
• Assay: ≥92% (HPLC)
• form: powder
• solubility: H₂O: 50 mg/mL
• storage temp.: −20°C
• SMILES string: [K+].[K+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C10H16N5O13P3.2K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;/q;2*+1/p-2/t4-,6-,7-,10-;;/m1../s1
• InChI key: YFPSRAQDZYNYPX-IDIVVRGQSA-L

Description

General description

Adenosine 5′-triphosphate (ATP) is synthesized in mitochondria by oxidative phosphorylation.

Application

Adenosine 5′-triphosphate dipotassium salt hydrate has been used:

• in in vitro transcription reaction as nucleotide source and in 2x RNA binding buffer
• as a component of energy solution for calibrating crude cell extract
• to test its dependency with PK11195 in mediating autophagy

Biochem/physiol Actions

Adenosine 5′-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is used in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. Metabolic disorders lead to ATP deficiency. Use of xanthine oxidoreductase inhibitors and inosine improves intracellular ATP levels.

P₂ purinergic agonist; increases activity of Ca²⁺-activated K⁺ channels; substrate for ATP-dependent enzyme systems.

Caution

For maximum stability, store as frozen solution at pH 3.5 to 6.8.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves