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Safety Information

C1879

Sigma-Aldrich

Choline chloride

≥98%

Synonym(s):

(2-Hydroxyethyl)trimethylammonium chloride

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About This Item

Linear Formula:
(CH3)3N(Cl)CH2CH2OH
CAS Number:
67-48-1
Molecular Weight:
139.62
Beilstein:
3563126
EC Number:
200-655-4
MDL number:
MFCD00011721
UNSPSC Code:
12352200
PubChem Substance ID:
57653990
NACRES:
NA.77

biological source

synthetic

Quality Level

200

Assay

≥98%

form

powder or crystals

technique(s)

cell culture | mammalian: suitable

color

colorless to white

mp

302-305 °C (dec.) (lit.)

SMILES string

[Cl-].C[N+](C)(C)CCO

InChI

1S/C5H14NO.ClH/c1-6(2,3)4-5-7;/h7H,4-5H2,1-3H3;1H/q+1;/p-1

InChI key

SGMZJAMFUVOLNK-UHFFFAOYSA-M

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General description

Choline chloride is the synthetic form of vitamin B4, choline and is a common poultry feed.

Application

Choline chloride has been used:
  • as a substrate for measuring choline oxidase enzyme activity using fluorescence measurements
  • as a component of non-physiological buffers for testing calcium based inhibition of cytochrome c oxidaseP
  • as a component of perfusate solution for studying arterial pressure in jejunum samples

Biochem/physiol Actions

Choline chloride treatment of radish seeds modulates phosphatidylcholine and phosphatidylethanolamine levels. It elicits hepatoprotective effects and modulates methyl carbon based metabolic pathways.

Substrates

Choline acetyltransferase substrate

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

C1879-VAR:
C1879-BULK:
C1879-500G:
C1879-1KG:
C1879-5KG:
C1879-100G:
C1879-25G:

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF2514V
WXBF4583V
WXBF3187V
WXBF4019V
WXBF2688V

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Cytochrome c oxidase inhibition by calcium at physiological ionic composition of the medium: Implications for physiological significance of the effect
Vygodina T, et al.
Biochimica et Biophysica Acta - Bioenergetics, 1858(12), 982-990 (2017)
Choline and methionine differentially alter methyl carbon metabolism in bovine neonatal hepatocytes
Chandler TL and White HM
PLoS ONE, 12(2), e0171080-e0171080 (2017)
Effect of choline chloride on the lipid content and composition in the leaves of principal magnetically-oriented radish types
Novitskaya GV, et al.
Russian Journal of Plant Physiology, 51(3), 361-371 (2004)
Rapid enzymatic method for the determination of phosphoryl choline using the fluorescence of the enzyme choline oxidase. Sequential determination of choline and phosphorylcholine in milk powder for children
Sanz-Vicente I, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 123, 259-266 (2015)
An investigation into the relationship between small intestinal fluid secretion and systemic arterial blood pressure in the anesthetized rat
Lucas ML and Morrison JD
Physiological Reports, 3(5) (2015)
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