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Safety Information

E8886

Sigma-Aldrich

Erythrosin extra bluish

Dye content, ≥80%, certified by the Biological Stain Commission, powder

Synonym(s):

2′,4′,5′,7′-Tetraiodofluorescein disodium salt, Acid Red 51, Iodoeosin

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About This Item

Empirical Formula (Hill Notation):
C20H6I4Na2O5
CAS Number:
16423-68-0
Molecular Weight:
879.86
Colour Index Number:
45430
Beilstein:
1443945
EC Number:
240-474-8
MDL number:
MFCD00144257
UNSPSC Code:
12171500
PubChem Substance ID:
24894685
NACRES:
NA.47

Product Name

Erythrosin extra bluish, certified by the Biological Stain Commission

grade

certified by the Biological Stain Commission

Quality Level

200

form

powder

composition

Dye content, ≥80%

pH

6.4 (30.3 °C)

mp

315 °C

solubility

water: 1 mg/mL, clear

density

0.625-0.731 g/cm3 at 30.1 °C

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].[Na+].[O-]c1c(I)cc2c(Oc3c(I)c([O-])c(I)cc3C24OC(=O)c5ccccc45)c1I

InChI

1S/C20H8I4O5.2Na/c21-11-5-9-17(13(23)15(11)25)28-18-10(6-12(22)16(26)14(18)24)20(9)8-4-2-1-3-7(8)19(27)29-20;;/h1-6,25-26H;;/q;2*+1/p-2

InChI key

RAGZEDHHTPQLAI-UHFFFAOYSA-L

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General description

Erythrosin extra bluish is soluble in ethanol and water. It is a brown powder, with a pH range of 2.5 to 4. It is used in color filters, light emitting diodes, cosmetics and hair dyes. It has been used in many biological applications such as, detecting gene expression, treating age related macular degeneration, diabetes and obesity.

Suitability

Certified for use in the Jackson stain for plant anatomy; counterstain for alum hematoxylin; Kreyberg′s method for keratin and mucus.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H302,H411

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

359.6 °F - closed cup

Flash Point(C)

182 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

E8886-BULK:
E8886-25G:4548173996400
E8886-VAR:

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Certificates of Analysis (COA)

Lot/Batch Number
SHBR6554
0000244685
SHBQ3587
SHBN5588
SHBL3062

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R W Sabnis.
Handbook of Acid-Base Indicators (2007)
R W Sabnis.
Handbook of Biological Dyes and Stains: Synthesis and Industrial Applications, 544-544 (2010)
Ying-Ju Huang et al.
ChemMedChem, 7(4), 571-577 (2012-02-23)
SecA is a central component of the general secretion system that is essential for bacterial growth and thus an ideal target for antimicrobial agents. A series of fluorescein analogues were first screened against the ATPase activity using the truncated unregulated
Juliana P M L Rolim et al.
Journal of photochemistry and photobiology. B, Biology, 106, 40-46 (2011-11-11)
Several photosensitizers have been used against oral bacteria without standardization. Singlet oxygen ((1)O(2)) is an aggressive chemical species that can kill cells through apoptosis or necrosis. to compare the antimicrobial activity of photodynamic therapy (PDT) with different photosensitizers at the
Anna Carolina Borges Pereira Costa et al.
Archives of oral biology, 56(11), 1299-1305 (2011-06-28)
The effect of erythrosine- and LED-mediated photodynamic therapy (PDT) on planktonic cultures and biofilms of Candida albicans and Candida dubliniensis was evaluated. Planktonic cultures of standardized suspensions (10(6)cells/mL) of C. albicans and C. dubliniensis were treated with erythrosine concentrations of
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