F4021
Follicle Stimulating Hormone from human pituitary
~7,000 IU/mg (powder)
Synonym(s):
FSH, Follitropin
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
biological source:
human pituitary glands
form:
powder
Recommended Products
biological source
human pituitary glands
Quality Level
sterility
non-sterile
form
powder
specific activity
~7,000 IU/mg (powder)
mol wt
35 kDa
technique(s)
cell culture | mammalian: suitable
impurities
HBsAg, HCV and HIV-1/HIV-2, tested negative
pH
7.4
solubility
water: ~50 g/L
shipped in
ambient
storage temp.
−20°C
Gene Information
human ... FSHB(2488) , FSHR(2492)
General description
The α chain of FSH has 89 amino acids and the β chain has 115 amino acids. The α chain is not active. FSH belongs to glycoprotein hormone family. It is secreted by the gonadotropic cells of pituitary gland.
Research area: Cell signaling
Research area: Cell signaling
Application
Follicle stimulating hormone (FSH) from human pituitary has been used for-
- in vitro luteinization of Macaque granulosa cells
- luteal cell proliferation assay
- culturing of preantral follicle cells obtained from mice
- in vitro maturation of immature cumulus-oocyte complexes (COCs) obtained from mice and
- culture of RAW264.7 cell line
Biochem/physiol Actions
FSH (follicle stimulating hormone) in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle-stimulating hormone receptor) interacts with FSH in the ovaries and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis. In the Caucasian population, certain polymorphisms in the FSHR gene are more commonly found in patients with polycystic ovary syndrome (PCOS). In the male fetuses and neonates, it facilitates the proliferation of Sertoli cells. In pubescent males, it stimulates spermatogonia to undergo mitosis.FSH upon binding to its receptor FSH-R positively regulates G-protein coupled receptors/cyclic adenosine monophosphate (cAMP)/protein kinase A pathways to cascade intracellular signals.
The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.
Packaging
Package size based on protein content
Other Notes
Two-chain glycoprotein hormone
Quality
Vial also contains 0.1 mg of salts from 0.05 M phosphate buffer, pH 7.4.
antibody
Product No.
Description
Pricing
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Listings
Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.
JAN Code
F4021-.1MG:
F4021-.1MG-PW:
F4021-2UG-PW:
F4021-25UG:
F4021-10UG:
F4021-25UG-PW:
F4021-2UG:
F4021-VAR:
F4021-10UG-PW:
F4021-BULK:
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Karenne N Fru et al.
Biology of reproduction, 75(4), 568-574 (2006-07-14)
Ovulation and luteal formation in primates are associated with the sustained synthesis of progesterone. The observed high intrafollicular concentrations of progesterone during the periovulatory interval raise the possibility that this steroid serves as a precursor for mineralocorticoids. The aim of
Y Figenschau et al.
Human reproduction (Oxford, England), 12(3), 523-531 (1997-03-01)
A simplified method for the preparation and long-term cultivation of granulosa-luteal cells in serum-free medium is described. The cells were harvested from women undergoing in-vitro fertilization, enriched by sedimentation and dissociated by enzymatic treatment. We demonstrated, by introducing a synthetic
J Wu et al.
Biology of reproduction, 63(1), 320-327 (2000-06-22)
Although it is known that LH receptors are present from the time of thecal differentiation, the role of LH during early follicle development is not yet clear. The effect of LH on preantral follicle development has therefore been investigated in
Alfredo Ulloa-Aguirre et al.
Endocrinology, 159(8), 3020-3035 (2018-07-10)
FSH is synthesized in the pituitary by gonadotrope cells. By binding to and interacting with its cognate receptor [FSH receptor (FSHR)] in the gonads, this gonadotropin plays a key role in the control of gonadal function and reproduction. Upon activation
Marina Grigorova et al.
The Journal of clinical endocrinology and metabolism, 96(9), E1534-E1541 (2011-07-08)
The detailed role of FSH in contributing to male testicular function and fertility has been debated. We have previously identified the association between the T-allele of the FSHB promoter polymorphism (rs10835638; G/T, -211 bp from the mRNA start) and significantly
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service