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G9885

Sigma-Aldrich

α1-Acid Glycoprotein from human plasma

≥99% (agarose gel electrophoresis)

Synonym(s):

AGP, Orosomucoid

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About This Item

CAS Number:
66455-27-4
MDL number:
MFCD00131224
UNSPSC Code:
12352202
NACRES:
NA.32

biological source

human plasma

Quality Level

200

Assay

≥99% (agarose gel electrophoresis)

form

powder

technique(s)

ELISA: suitable

impurities

HIV-1/HIV-2, HCV and hepatitis B antigen, tested negative

UniProt accession no.

P02763

storage temp.

2-8°C

Gene Information

human ... ORM1(5004)

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General description

α-1-Acid glycoprotein (AGP)/orosomucoid (ORM), a glycoprotein has a molecular weight of 41-43kDa. It is considered as one of the important acute phase proteins in humans and rats. AGP may belong to the lipocalin family.

Application

α1-Acid glycoprotein from human plasma has been used:
  • as negatively charged protein to investigate the adsorption processes onto the surface of polyelectrolyte multilayers
  • to incubate plates coated with purified antiserum in the study to investigate its serum concentration by ELISA
  • to study the effect of its different concentrations on the antiviral activity of human immunodeficiency virus (HIV) protease inhibitors

Biochem/physiol Actions

α1-Acid glycoprotein possesses immunomodulating effects. It has the ability to bind to acidic drugs, like phenobarbital.

Preparation Note

Purified from Cohn Fraction VI

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

G9885-VAR:
G9885-10MG:
G9885-250MG:
G9885-25MG:
G9885-5MG:
G9885-BULK:
G9885-100MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000430269
0000430268
0000430267
0000430267
0000430268

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In Vitro Effect of alpha1-Acid Glycoprotein on the Anti?Human Immunodeficiency Virus (HIV) Activity of the Protease Inhibitor CGP 61755: A Comparative Study with Other Relevant HIV Protease Inhibitors
Lazdins J K, et al.
The Journal of Infectious Diseases, 175(5), 1063-1070 (1997)
Hendrik Grootaert et al.
Glycobiology, 30(9), 735-745 (2020-03-10)
The deoxy sugar l-fucose is frequently found as a glycan constituent on and outside living cells, and in mammals it is involved in a wide range of biological processes including leukocyte trafficking, histo-blood group antigenicity and antibody effector functions. The
Chenhua Zhang et al.
Analytica chimica acta, 1078, 189-199 (2019-07-31)
Silica-based lectin microcolumns were developed and optimized for the separation and analysis of glycoform fractions in alpha1-acid glycoprotein (AGP) based on both the degree of branching and level of fucosylation. Concanavalin A (Con A) and Aleuria Aurantia lectin (AAL) were
Jae Woong Choi et al.
Journal of microbiology and biotechnology, 30(9), 1297-1304 (2020-07-07)
Elevated serum levels of alpha-1-acid glycoprotein (AGP) are known to be associated with several types of cancer. In addition, some reports have indicated that changes in glycosylation of AGP are associated with cancer progression. However, changes in AGP levels of
Effect of once weekly administration of mifepristone on ovarian function in normal women
Chen X and Xiao B
Contraception, 56(3), 175-180 (1997)
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