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Safety Information

J4455

Sigma-Aldrich

JSH-23

≥98% (HPLC), solid

Synonym(s):

4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

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About This Item

Empirical Formula (Hill Notation):
C16H20N2
CAS Number:
749886-87-1
Molecular Weight:
240.34
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

storage condition

protect from light

color

off-white to gray-pink

solubility

DMSO: >10 mg/mL

shipped in

wet ice

storage temp.

−20°C

InChI

1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3

InChI key

YMFNPBSZFWXMAD-UHFFFAOYSA-N

Application

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

Biochem/physiol Actions

JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

Other Notes

Light and air sensitive.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

J4455-VAR:
J4455-BULK:
J4455-IP:
J4455-5MG:
J4455-25MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Transcription factor 4 (TCF-4) was recently identified as a candidate gene for the cause of type 2 diabetes, although the mechanisms have not been fully elucidated. In the present study, we demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet
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