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Safety Information

L6895

Sigma-Aldrich

Lipid A, monophosphoryl from Salmonella enterica serotype minnesota Re 595 (Re mutant)

lyophilized powder, TLR ligand tested

Synonym(s):

Monophosphoryl Lipid A from Salmonella

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About This Item

MDL number:
MFCD00131511
UNSPSC Code:
12352211
NACRES:
NA.25

biological source

Salmonella enterica (serotype minnesota Re 595 Re mutant)

Quality Level

300

form

lyophilized powder

impurities

<0.2% Ketodeoxyoctonate (KDO)

shipped in

ambient

storage temp.

2-8°C

Related Categories

Application

Lipid A molecules compose the lipid membrane anchoring core components of endotoxins produced by Gram-negative bacteria. Lipid A molecules induce immune responses. Structually, lipid A molecules are composed of two glucosamine units with varied, species dependent, fatty acyl chain numbers and identity and degree of phosphorylation.
Lipid A, monophosphoryl from Salmonella enterica serotype minnesota Re 595 may be used in comparative assessment of the antigenicity of specific structures within different LPA molecules and analogues.

Biochem/physiol Actions

Lipid A has immunostimulatory adjuvant activity including macrophage, T-cell, and B-cell activation. Research has shown Lipid A has greater Th1 than Th2 stimulation.
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

L6895-VAR:
L6895-1MG-PW:
L6895-1MG:
L6895-5MG:
L6895-5MG-PW:
L6895-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
0000390697
0000390698
0000376935
0000359551
0000373972

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Tyler J Van De Voort et al.
Journal of immunotherapy (Hagerstown, Md. : 1997), 36(1), 29-40 (2012-12-06)
In this study, an agonistic anti-CD40 monoclonal antibody was combined with monophosphoryl lipid A (MPL), a nontoxic derivative of lipopolysaccharide and agonist of toll-like receptor-4, to assess the immunomodulatory and antitumor synergy between the 2 agents in mice. Anti-CD40 was
Melissa C Hanson et al.
Vaccine, 33(7), 861-868 (2015-01-07)
An HIV vaccine capable of inducing high and durable levels of broadly neutralizing antibodies has thus far proven elusive. A promising antigen is the membrane-proximal external region (MPER) from gp41, a segment of the viral envelope recognized by a number
Tarik A Khan et al.
Science advances, 2(3), e1501371-e1501371 (2016-03-22)
High-throughput antibody repertoire sequencing (Ig-seq) provides quantitative molecular information on humoral immunity. However, Ig-seq is compromised by biases and errors introduced during library preparation and sequencing. By using synthetic antibody spike-in genes, we determined that primer bias from multiplex polymerase
Subhashini Jagu et al.
Vaccine, 28(28), 4478-4486 (2010-05-04)
Immunization with L1 as pentavalent capsomeres or virus-like particles (VLPs) generates high and long-lived titers of neutralizing antibodies and protection primarily against the human papillomavirus (HPV) type from which the vaccine was derived. Conversely, vaccination with L2 minor capsid protein
S Hutchison et al.
Veterinary immunology and immunopathology, 216, 109912-109912 (2019-08-26)
Melanoma in humans and canines is an aggressive and highly metastatic cancer. The mucosal forms in both species share genetic and histopathologic features, making dogs a valuable spontaneous disease animal model. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of
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