Skip to Content
Merck
All Photos(2)

Key Documents

View All Documentation

Safety Information

L9170

Sigma-Aldrich

Lipodisq®

Styrene: Maleic Anhydride Copolymer 3:1, Pre-hydrolyzed, powder, from synthetic

Synonym(s):

Lipid nanoparticle, Liposomal delivery system

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

UNSPSC Code:
12352202
NACRES:
NA.26

biological source

synthetic

Quality Level

200

Assay

98-100%

form

powder

mol wt

9500 Da

storage condition

(Keep container tightly closed in a dry and well-ventilated place
Keep in a dry place)

storage temp.

room temp

Looking for similar products? Visit Product Comparison Guide

General description

Research area: Cell Structure

Lipodisq® polymers contain styrene and maleic acid monomer units. This product is the pre-hydrolyzed form of the SMA polymer, with styrene and maleic acid monomers. These polymer-lipid complexes are mainly generated by detergent-free methods.

Functional pH range: 6.0 - 9.0

Application

Lipodisq® reagents are novel polymers derived from styrene and maleic acid. Lipodisq polymers are capable of forming nanosized lipid-based discoidal particles capable of incorporating membrane proteins. The Lipodisq technology can solubilize commonly used lipids such as dimyristoylphosphatidylcholine (DMPC) without the use of detergents. In general, Lipodisq polymers are potentially useful in mitigating the use of detergents for the solubilization of membrane proteins. Lipodisqs typically have a diameter of 9-10 nm at pH 7.4.

Legal Information

Lipodisq is a registered trademark of Malvern Cosmeceutics Limited

related product

Product No.
Description
Pricing

427845

Polypropylene-graft-maleic anhydride, viscosity 425 cPs

416320

Poly(methyl vinyl ether-alt-maleic anhydride), average Mw ~1,080,000, average Mn ~311,000

416339

Poly(methyl vinyl ether-alt-maleic anhydride), average Mw ~216,000, average Mn ~80,000

188050

Poly(ethylene-alt-maleic anhydride), average Mw 100,000-500,000, powder

434558

Poly(4-styrenesulfonic acid-co-maleic acid) sodium salt, average Mw ~20,000, powder

531278

Poly(isobutylene-alt-maleic anhydride), average Mw ~6,000, 12-200 mesh (85%)

531367

Poly[(isobutylene-alt-maleic acid, ammonium salt)-co-(isobutylene-alt-maleic anhydride)], average Mw ~60,000

460060

Polyisoprene-graft-maleic anhydride, average Mw ~25,000

662631

Poly(styrene-alt-maleic acid) sodium salt solution, 13 wt. % in H2O

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

L9170-BULK:
L9170-500MG:
L9170-100MG:
L9170-VAR:

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000376021
0000376021
SLCQ3561
SLCN7891
SLCL4635

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 2

1 of 2

14:0 PC (DMPC) 1,2-dimyristoyl-sn-glycero-3-phosphocholine, powder

Avanti

850345P

14:0 PC (DMPC)

PMA Avanti Research™ - A Croda Brand (880134P), powder

Avanti

880134P

PMA

Indra D Sahu et al.
Biochemistry, 52(38), 6627-6632 (2013-08-30)
Pulsed EPR DEER structural studies of membrane proteins in a lipid bilayer have often been hindered by difficulties in extracting accurate distances when compared to those of globular proteins. In this study, we employed a combination of three recently developed
Juan F Bada Juarez et al.
Chemistry and physics of lipids, 222, 51-58 (2019-05-19)
Lipodisq™ nanoparticles have been used to extract surface lipids from the cuticle of two strains (wild type, N2 and the bacteria-resistant strain, agmo-1) of the C. elegans nematode without loss of viability. The extracted lipids were characterized by thin layer
Maria Lyngaas Torgersen et al.
Journal of biomedical nanotechnology, 16(4), 419-431 (2020-09-25)
Many promising pharmaceutically active compounds have low solubility in aqueous environments and their encapsulation into efficient drug delivery vehicles is crucial to increase their bioavailability. Lipodisq nanoparticles are approximately 10 nm in diameter and consist of a circular phospholipid bilayer
Masafumi Tanaka et al.
Chemistry and physics of lipids, 232, 104954-104954 (2020-08-23)
Lipid emulsions are potential carriers for poorly water-soluble drugs. Previously, we revealed that lipid nanoparticles complexed with styrene maleic acid copolymer (SMA) disintegrate under acidic pH. In the present study, SMA-containing lipid emulsions (SMA emulsions) were prepared and their physicochemical
Detergent-Free Formation and Physicochemical Characterization of Nanosized Lipid-Polymer Complexes: Lipodisq
Orwick MC, et al.
Angewandte Chemie (International ed. in English), 51(19), 4653-4657 (2012)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service