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Safety Information

M0567

Sigma-Aldrich

Microsomes from Liver, Pooled

from human male

Synonym(s):

lab equipment accessory

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About This Item

UNSPSC Code:
12352204
NACRES:
NA.54

biological source

human male

Quality Level

200

form

liquid

packaging

vial of ~10 mg

shipped in

dry ice

storage temp.

−70°C

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Application

Microsomes from Liver, Pooled has been used:
  • in the glucuronidation kinetics assay to test the effects of herbal extracts on glucuronidation process
  • as a human liver microsomes (HLM) matrix for testing metabolic stability of talazoparib using liquid chromatography-tandem mass spectrometry (LC–MS/MS)
  • to study the metabolization of enantiomeric peptide D3

Microsomes from liver have been used in a study to assess differences in enzymatic activities between normal rat livers and from liver after partial hepatectomy. They have also been used in a study to investigate the carbon monoxide-binding pigment in liver microsomes.

Biochem/physiol Actions

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
N-glucuronidation of various 1-substituted imidazoles was found to occur in human liver microsomes.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

M0567-1VL:
M0567-VAR:
M0567-BULK:
M0567-1VL-PW:

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Certificates of Analysis (COA)

Lot/Batch Number
SLCP2578
SLCN6884
SLCL7266
SLCH6952
SLCD4391

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Ali S Abdelhameed et al.
Royal Society open science, 6(6), 190434-190434 (2019-07-18)
Spebrutinib (SBT) is a Bruton's tyrosine kinase inhibitor. SBT is currently in phase II and phase I clinical trials for the management of rheumatoid arthritis and chronic lymphocytic leukaemia, respectively. We developed and validated a liquid chromatography tandem mass spectrometry
Ali S Abdelhameed et al.
Drug design, development and therapy, 14, 5259-5273 (2020-12-11)
Ensartinib (ESB) is a novel anaplastic lymphoma kinase inhibitor (ALK) with additional activity against Abelson murine leukemia (ABL), met proto-oncogene (MET), receptor tyrosine kinase (AXL), and v-ros UR2 sarcoma virus oncogene homolog 1 (ROS1) and is considered a safer alternative
Anne Elfgen et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 107, 203-207 (2017-07-18)
The aggregation of the amyloid β protein (Aβ) plays an important role in the pathology of Alzheimer's disease. Previously, we have developed the all-d-enantiomeric peptide D3, which is able to eliminate neurotoxic Aβ oligomers in vitro and improve cognition in
Sarvesh C Vashishtha et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(10), 1070-1076 (2002-09-14)
N-Glucuronidation at an aromatic tertiary amine of 5-membered polyaza ring systems was investigated for a model series of eight 1-substituted imidazoles in liver microsomes from five species. The major objectives were to investigate substrate specificities of the series in human
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.
T OMURA et al.
The Journal of biological chemistry, 239, 2370-2378 (1964-07-01)
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