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Safety Information

P9156

Sigma-Aldrich

Plasminogen from bovine plasma

lyophilized powder, ≥2.0 units/mg protein

Synonym(s):

Profibrinolysin

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About This Item

CAS Number:
9001-91-6
EC Number:
232-641-9
MDL number:
MFCD00131922
UNSPSC Code:
12352202
eCl@ss:
42030240
NACRES:
NA.61

biological source

bovine plasma

Quality Level

200

form

lyophilized powder

specific activity

≥2.0 units/mg protein

concentration

2-7% protein (biuret)

suitability

not suitable for streptokinase determination by clot formation procedure

UniProt accession no.

P00747
P06868

application(s)

histology

storage temp.

2-8°C

Gene Information

cow ... PLG(280897)
human ... PLG(5340)

Biochem/physiol Actions

The activated form of plasminogen, plasmin, was shown to promote the migration of melanoma and lung tumor cells plated on the extracellular matrix protein laminin by altering protein kinase C signaling.
Plasminogen is the inactive precursor of the protease plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration. Plasmin cleaves fibrin/fibrinogen and blood coagulation factors V/Va and VIII/VIIIa. It activates matrix metalloproteinases by cleaving the inactive proenzymes. It is also involved in the activation of some growth factors, such as vascular endothelial growth factor (VEGF) and transforming growth factor β (TGF-β).

Other Notes

ε-Aminocaproic acid free

Unit Definition

One unit will produce 1.0 μmole of p-nitroanilide from D-Val-Leu-Lys 4-nitroanilide at pH 7.5 at 37°C.

Physical form

Lyophilized powder containing NaCl, EDTA, lysine, and Tris buffer salts

Reconstitution

Solutions should be stored in buffer containing 20 mM lysine at neutral pH. The protein should be as concentrated as possible. Frozen in aliquots at −20 °C, it should be stable for several weeks.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P9156-5UN-PW:
P9156-25UN:
P9156PROC:
P9156-10UN:
P9156-5UN:
P9156-VAR:
P9156-PH:
P9156-25UN-PW:
P9156-10UN-PW:
P9156-100UN-PW:
P9156-1UN:
P9156-100UN:
P9156-BULK:

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Certificates of Analysis (COA)

Lot/Batch Number
SLBV6658
041M7019
096K7540
123K7450
119F94542

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L Chikahisa et al.
Invasion & metastasis, 17(6), 323-333 (1997-01-01)
Using a pure chemotactic model, we investigated the effect of plasmin on tumor cell motility. In the presence of various extracellular matrix proteins, plasmin facilitated motility of human melanoma LOX and lung cancer Lu-99 cells. Laminin contributed most to the
Sudan Puri et al.
Stem cell research & therapy, 13(1), 384-384 (2022-07-31)
Hyaluronan (HA) has previously been identified as an integral component of the limbal stem cell niche in vivo. In this study, we investigated whether a similar HA matrix is also expressed in vitro providing a niche supporting limbal epithelial stem
Yueling Zhang et al.
FEBS letters, 587(9), 1304-1309 (2013-03-12)
Cluster 1 streptokinases (SK1) from Streptococcus pyogenes (GAS) show substantially higher human plasminogen (hPg) activation activities and tighter hPg binding affinities than cluster 2b streptokinases (SK2b) in solution. The extent to which the different domains of SK are responsible for
Barbara Ruszkowska et al.
Acta obstetricia et gynecologica Scandinavica, 92(7), 841-846 (2013-03-12)
To assess the concentration of adiponectin, soluble E-selectin, soluble thrombomodulin and tissue activator plasminogen antigen in postmenopausal women who received oral or transdermal hormone therapy. Case-control study. Polish university hospitals. Seventy-six healthy postmenopausal women. Forty-six women who received oral (n
Lina Ma et al.
Se pu = Chinese journal of chromatography, 30(8), 822-826 (2012-12-22)
The Kringle 5 domain of plasminogen is one of the most potent angiogenesis inhibitors known to date, which can inhibit cell proliferation and migration efficiently. In the study, on the foundation of successful clone and expression of recombinant soluble and
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