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Key Documents

Safety Information

SML0797

Sigma-Aldrich

Flibanserin

≥98% (HPLC)

Synonym(s):

1,3-Dihydro-1-[2-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]ethyl]-2H-benzimidazol-2-one, BIMT 17, BIMT 17BS

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About This Item

Empirical Formula (Hill Notation):
C20H21F3N4O
CAS Number:
167933-07-5
Molecular Weight:
390.40
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

FC(F)(F)c1ccc(cc1)N2CCN(CC2)CC[n]3c4c([nH][c]3=O)cccc4

InChI

1S/C20H21F3N4O/c21-20(22,23)15-5-7-16(8-6-15)26-12-9-25(10-13-26)11-14-27-18-4-2-1-3-17(18)24-19(27)28/h1-8H,9-14H2,(H,24,28)

InChI key

CCIZQGRSEAHATK-UHFFFAOYSA-N

Biochem/physiol Actions

Flibanserin is a 5-HT1A receptor agonist and 5-HT2A receptor antagonist.
Flibanserin is a 5-HT1A receptor agonist and 5-HT2A receptor antagonist. Flibanserin has high affinity for human 5-HT1A receptors (Ki = 1 nm) and lower affinity for 5-HT2A (Ki = 49 nm) and D4 (Ki = 4–24 nm) receptors, and negligible affinity for a variety of other neurotransmitter receptors and ion channels. Flibanserin was investigated as a novel, non-hormonal treatment for pre-menopausal women with Hypoactive Sexual Desire Disorder (HSDD). Flibanserin. Recently, Flibanserin was found to reduce L-DOPA-induced dyskinesia in a model of Parkinson′s Disease.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H315,H319,H335

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML0797-BULK:
SML0797-VAR:
SML0797-5MG:
SML0797-25MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000121598
0000121599
0000115092
0000085675
0000085676

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Resurgence of interest in sexual dysfunction?
Mike G Wyllie
BJU international, 109(11), E36-E37 (2012-05-09)
[Normality of the female libido (1)].
Jean-Yves Nau
Revue medicale suisse, 6(255), 1378-1379 (2010-08-06)
Stephen M Stahl et al.
The journal of sexual medicine, 8(1), 15-27 (2010-09-16)
Flibanserin is a novel pharmacologic agent in late-stage clinical testing for hypoactive sexual desire disorder (HSDD) in premenopausal women. The aim of this article is to review the hypothetical mechanism of action of flibanserin in HSDD. A literature review was
Consultation corner. The latest on female sexual health.
Leonard R DeRogatis
The Johns Hopkins medical letter health after 50, 22(9), 6-7 (2010-11-12)
Yves Aubert et al.
The journal of sexual medicine, 9(3), 694-707 (2012-02-07)
Psychopathological origins of personally distressing, hypoactive sexual desire disorder (HSDD) in women are unknown, but are generally attributed to an inhibitory neural regulator, serotonin (5-HT). Flibanserin, a 5-HT(1A) agonist and 5-HT(2A) antagonist, shows promise as a treatment for HSDD. To
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