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Safety Information

SML3699

Sigma-Aldrich

G140

≥98% (HPLC)

Synonym(s):

1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-yl)-2-hydroxyethanone, T015T-010-1

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About This Item

Empirical Formula (Hill Notation):
C17H16Cl2N4O2
CAS Number:
Molecular Weight:
379.24
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.21

Quality Level

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Biochem/physiol Actions

Substrate site-targeting, non-cytotoxic, potent and selective human cyclic GMP-AMP synthase (cGAS) inhibitor against cellular STING signaling.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3699-BULK:
SML3699-VAR:
SML3699-5MG:
SML3699-25MG:


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Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Nature Communications, 10(1), 2261-2261 (2019)

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