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Safety Information

1607007

USP

Saccharin

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide, 2-Sulfobenzoic acid imide, o-Benzoic sulfimide

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About This Item

Empirical Formula (Hill Notation):
C7H5NO3S
CAS Number:
81-07-2
Molecular Weight:
183.18
Beilstein:
6888
MDL number:
MFCD00005866
UNSPSC Code:
41116107
PubChem Substance ID:
329751066
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

saccharin

manufacturer/tradename

USP

mp

226-229 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

O=C1NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)

InChI key

CVHZOJJKTDOEJC-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Saccharin USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Saccharin Sodium Tablets

Biochem/physiol Actions

A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

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Description
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1672010

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1672020

p-Toluenesulfonamide, United States Pharmacopeia (USP) Reference Standard

S0050000

Saccharin sodium, European Pharmacopoeia (EP) Reference Standard

PHR1348

Saccharin Sodium, Pharmaceutical Secondary Standard; Certified Reference Material

S0040000

Saccharin, European Pharmacopoeia (EP) Reference Standard

1607040

Saccharin sodium salt dihydrate, United States Pharmacopeia (USP) Reference Standard

1607029

Saccharin calcium, United States Pharmacopeia (USP) Reference Standard

PHR1473

o-Toluenesulfonamide, Pharmaceutical Secondary Standard; Certified Reference Material

PHR1474

p-Toluenesulfonamide, Pharmaceutical Secondary Standard; Certified Reference Material

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

1607007-200MG:

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The toxicological effects of saccharin in short-term genotoxicity assays.
D L Arnold et al.
Mutation research, 221(2), 69-132 (1989-09-01)
J Whysner et al.
Pharmacology & therapeutics, 71(1-2), 225-252 (1996-01-01)
Sodium saccharin (NaSac) produces bladder tumors consistently in male rats only after lifetime exposure that begins at birth. NaSac is not metabolized and is negative in most genotoxicity tests. NaSac-induced cell damage and proliferation have been proposed as important factors
R L Anderson
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 26(7), 637-644 (1988-07-01)
An hypothesis is presented of a mechanism for the sodium saccharin (NaS)-associated tumorigenesis of the urinary bladder that occurs in male rats. The ingestion of high doses of NaS is associated with increased urine volume and bladder mass. In rats
D L Arnold et al.
Toxicology, 27(3-4), 179-256 (1983-07-01)
Saccharin, first synthesized in 1879, eventually became popular as an inexpensive substitute for sugar, particularly as a non-caloric sweetner. The dispute concerning the safety of saccharin for human consumption is almost as old as saccharin itself. In this article, the
L B Ellwein et al.
Critical reviews in toxicology, 20(5), 311-326 (1990-01-01)
Almost from its discovery in 1879, the use of saccharin as an artificial, non-nutritive sweetener has been the center of several controversies regarding potential toxic effects, most recently focusing on the urinary bladder carcinogenicity of sodium saccharin in rats when
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