SAB4200776

Anti-TUBA1A (TUBA3) Antibody

mouse monoclonal, TUB-1A2

• 別名: Tubulin Alpha-1 Chain
• UNSPSCコード: 12352203
• NACRES: NA.41

特性

• 製品名: Anti-Tubulin, Tyrosine antibody, Mouse monoclonal, clone TUB-1A2, purified from hybridoma cell culture
• 由来生物: mouse
• 品質水準: 200
• 抗体製品の状態: purified from hybridoma cell culture
• 抗体製品タイプ: primary antibodies
• クローン: TUB-1A2, monoclonal
• フォーム: buffered aqueous solution
• 分子量: ~55 kDa
• 交差性: Xenopus, Arabidopsis sp., yeast, insect, rat, hamster, porcine, monkey, bovine, human, mouse, canine, chicken
• 濃度: ~1 mg/mL
• テクニック: immunoblotting: suitable; immunofluorescence: 2-4 μg/mL using human HeLa or Chicken fibroblast cells; immunohistochemistry: suitable
• アイソタイプ: IgG3
• UniProtアクセッション番号: Q71U36
• 輸送温度: dry ice
• 保管温度: −20°C
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... TUBA1A(7846)

詳細

詳細

Anti-Tubulin, Tyrosine antibody, Mouse monoclonal (mouse IgG3 isotype) is derived from the TUB-1A2 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from mouse. Tubulin is an intracellular cylindrical filamentous structure and is presented in eukaryotic cells. It consists of three isoforms α-, β- and γ-tubulin. Tubulin is a heterodimer of α- and β- tubulin subunits.

特異性

Anti-Tubulin, Tyrosine antibody, Mouse monoclonal specifically recognizes the C-terminal Tyrosine of Tubulin protein. The antibody is non-reactive with cells that have been treated with pancreatic carboxypeptidase A under conditions which remove only the C-terminal tyrosine. Monoclonal Anti-Tubulin, Tyrosine recognizes Tubulin from human, mouse, chicken, bovine, rat, hamster, canine, monkey, porcine, arabidopsis, tobacco, yeast, Xenopus, insect, comb jelly, sponge, and worm origin.

免疫原

a synthetic peptide containing the carboxy terminal amino acids of porcine a-tubulin

アプリケーション

Anti-Tubulin, Tyrosine antibody, mouse monoclonal may be used in:

• immunoblotting
• immunofluorescence
• immunohistochemistry

生物化学的／生理学的作用

Tubulin is the major building block of microtubules which is essential for structural and mobility elements in mitosis, intracellular transport, flagellar movement and in the cytoskeleton. It is also involved in the nervous system. Tubulin is associated with neurodegenerative disorders such as Alzheimer′s and Parkinson′s disease. Mutations in the αβ- dimers and γ-tubulin are associated with malformation and impairment of cognitive disorders.

物理的形状

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

保管および安定性

For continuous use, store at 2–8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免責事項

Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable