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202487

Sigma-Aldrich

Poly(ethylene glycol) methyl ether

average MN 550, methoxy, hydroxyl

Synonym(s):

Polyethylene glycol, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG

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About This Item

Linear Formula:
CH3(OCH2CH2)nOH
CAS Number:
9004-74-4
MDL number:
MFCD00084416
UNSPSC Code:
12162002
PubChem Substance ID:
24852066
NACRES:
NA.23

Product Name

Poly(ethylene glycol) methyl ether, average Mn 550

vapor density

>1 (vs air)

Quality Level

200

vapor pressure

0.05 mmHg ( 20 °C)

form

semisolid

mol wt

average Mn 550

refractive index

n20/D 1.455

viscosity

7.5 cSt(210 °F)(lit.)

transition temp

Tm 20 °C

density

1.089 g/mL at 25 °C

Ω-end

hydroxyl

α-end

methoxy

SMILES string

O(CCO)C

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

InChI key

XNWFRZJHXBZDAG-UHFFFAOYSA-N

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Application

Poly(ethylene glycol) methyl ether can be used as a pore-forming agent to prepare polysulfone membranes with enhanced hydrophilicity.

Poly(ethylene glycol) methyl ether-grafted polyamidoamine (PAMAM) dendrimers can be used as drug carrier systems for anticancer drugs.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

359.6 °F - closed cup

Flash Point(C)

182 °C - closed cup

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Certificates of Analysis (COA)

Lot/Batch Number
0000377733
0000319951
0000319951
0000377733
0000249498

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Polyethylene glycol dimethyl ether 500 (stabilised) for synthesis

Sigma-Aldrich

8.14171

Polyethylene glycol dimethyl ether 500

Yiyi Yu et al.
Journal of pharmaceutical sciences, 102(3), 1054-1062 (2013-01-03)
To promote the application of methoxy poly(ethylene glycol)-cholesterol (mPEG-Chol), mPEG-Chol was used to prepare core-shell micelles encapsulating poorly water-soluble docetaxel (DTX-PM) by modified cosolvent evaporation method. Approaches to enhance DTX entrapment efficiency (EE) and minimize particle size were investigated in
Pengxiang Zhao et al.
Chemical communications (Cambridge, England), 49(31), 3218-3220 (2013-03-14)
"Click" chemistry now offers access to a great variety of triazoles, and the first example of a strategy to stabilize gold nanoparticles (AuNPs) with a new 1,2,3-triazole-mPEG ligand is developed here together with preliminary examples of possible applications.
Mulu Z Tesfay et al.
Journal of virology, 87(7), 3752-3759 (2013-01-18)
We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized in the bone marrow. One of the presumed advantages for using VSV as an oncolytic
Seung-Young Lee et al.
Biomaterials, 34(2), 552-561 (2012-10-20)
Although targeted delivery mediated by ligand modified or tumor microenvironment sensitive nanocarriers has been extensively pursued for cancer chemotherapy, the efficiency is still limited by premature drug release after systemic administration. Herein we report a highly blood-stable, tumor-adaptable drug carrier
Hyo Won Seo et al.
Biomaterials, 34(11), 2748-2757 (2013-01-25)
The effectiveness of systemically administered anticancer treatments is limited by difficulties in achieving therapeutic doses within tumors, a problem that is complicated by dose-limiting side effects to normal tissue. To increase the efficacy and reduce the toxicity of systemically administered
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