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224936

Sigma-Aldrich

4-(Trifluoromethyl)aniline

99%

Synonym(s):

α,α,α-Trifluoro-p-toluidine, 4-Aminobenzotrifluoride

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About This Item

Linear Formula:
CF3C6H4NH2
CAS Number:
455-14-1
Molecular Weight:
161.12
Beilstein:
1564853
EC Number:
207-236-5
MDL number:
MFCD00064396
UNSPSC Code:
12352100
PubChem Substance ID:
24853465
NACRES:
NA.22

Assay

99%

form

liquid

refractive index

n20/D 1.483 (lit.)

bp

83 °C/12 mmHg (lit.)

density

1.283 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

Nc1ccc(cc1)C(F)(F)F

InChI

1S/C7H6F3N/c8-7(9,10)5-1-3-6(11)4-2-5/h1-4H,11H2

InChI key

ODGIMMLDVSWADK-UHFFFAOYSA-N

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Application

4-(Trifluoromethyl)aniline was used in the synthesis of 4-(trialkylmethyl)anilines. It was also used as a synthetic building block.

Signal Word

Danger

Hazard Statements

H301,H318,H410

Hazard Classifications

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tetrahedron Letters, 48, 4749-4749 (2007)
Meritxell Guinó et al.
The Journal of organic chemistry, 72(16), 6290-6293 (2007-07-13)
Optically active torcetrapib was synthesized in seven steps from achiral precursors without the need for protecting groups, utilizing an enantioselective aza-Michael reaction to achieve asymmetry.
A Facile Synthesis of 4-(Trialkylmethyl) anilines by the Reaction of 4-(Trifluoromethyl) aniline with Grignard Reagents.
Synthetic Communications, 27(11), 1975-1980 (1997)
P M Sharp
Gene, 139(1), 135-136 (1994-02-11)
Three previously unrecognized genes from Bacillus licheniformis, Thermus thermophilus and Thermotoga maritima, encoding ribosomal protein L33, have been identified and designated as rpmG genes. Their sequence and context have been compared with the three known rpmG genes from Escherichia coli
S H Coleman et al.
Journal of general microbiology, 139(4), 707-716 (1993-04-01)
The rpmB,G operon of Escherichia coli codes for the synthesis of ribosomal proteins L28 and L33. In one mutant strain (TP28), these two proteins are made at about half their normal rates, ribosome assembly is greatly perturbed and precursor particles
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