328014
3-Methylhippuric acid
98%
Synonym(s):
N-(3-Methylbenzoyl)glycine, m-Toluric acid
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About This Item
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Assay
98%
mp
138-140 °C (lit.)
SMILES string
Cc1cccc(c1)C(=O)NCC(O)=O
InChI
1S/C10H11NO3/c1-7-3-2-4-8(5-7)10(14)11-6-9(12)13/h2-5H,6H2,1H3,(H,11,14)(H,12,13)
InChI key
YKAKNMHEIJUKEX-UHFFFAOYSA-N
Related Categories
General description
3-Methylhippuric acid is also referred as m-methyl-hippuric acid. It is major product of xylene biotransformation in urine.
Application
3-Methylhippuric acid was employed as biological marker in studies on occupational exposure to xylene (solvent).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Occupational and environmental medicine, 51(3), 187-191 (1994-03-01)
This study was undertaken to determine whether previous subacute treatment with ethanol could modify the kinetics of m-xylene in humans. A group of six volunteers was exposed twice to either 100 or 400 ppm of m-xylene during two hours (between
Possible preferential metabolism of xylene isomers following occupational exposure to mixed xylenes.
International archives of occupational and environmental health, 72(2), 89-97 (1999-04-10)
Solvent exposures commonly involve mixtures of substances or mixtures of isomers of a single solvent. These may be metabolised through common pathways, resulting in the potential for metabolic interactions. These may then lead to accumulation of solvent or metabolic intermediates
Determination of methylhippuric acid in human urine by high-performance liquid chromatography and by isotachophoresis.
Journal of chromatography, 343(2), 419-423 (1985-10-11)
Journal of chromatography, 573(2), 318-322 (1992-01-17)
A high-performance liquid chromatographic method is described for the simultaneous determination of six urinary metabolites of several aromatic chemicals: phenol (from benzene), hippuric acid (from toluene), 3-methylhippuric acid (from xylene), mandelic and phenylglyoxylic acid (from styrene) and 4-nitrophenol (from nitrobenzene).
British journal of industrial medicine, 45(2), 127-132 (1988-02-01)
In a series of experiments to investigate interactions between industrial solvents and common medications the interaction between m-xylene and aspirin was studied. As both these substances are metabolised and excreted as glycine conjugates there would possibly be competition for this
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