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909769

Sigma-Aldrich

Folate-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

PEG average Mn 2,000, PLGA average Mn 10,000, lactide:glycolide 50:50

Synonym(s):

Biotin-PEG-PLGA, Polyethylene glycol

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About This Item

Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nC25H29N11O8
UNSPSC Code:
51171641
NACRES:
NA.23

form

powder or chunks

feed ratio

lactide:glycolide 50:50

mol wt

PEG average Mn 2,000 (by NMR)
PLGA average Mn 10,000 (by NMR)

color

white to tan

storage temp.

−20°C

Related Categories

Application

Folate-poly(ethylene glycol)-b-poly(lactide-co-glycolide) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLGA block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). The folate functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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MKCW5237
MKCL3507

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Miles A Miller et al.
Nature communications, 6, 8692-8692 (2015-10-28)
Therapeutic nanoparticles (TNPs) aim to deliver drugs more safely and effectively to cancers, yet clinical results have been unpredictable owing to limited in vivo understanding. Here we use single-cell imaging of intratumoral TNP pharmacokinetics and pharmacodynamics to better comprehend their
Jijin Gu et al.
Molecular pharmaceutics, 12(8), 2889-2903 (2015-06-24)
The goal of this study was to develop and characterize a novel intravaginal film platform for targeted delivery of small interfering RNA (siRNA)-loaded nanoparticles (NP) to dendritic cells as a potential gene therapy for the prevention of sexually transmitted human
Soroush Ardekani et al.
Scientific reports, 5, 16258-16258 (2015-11-21)
Nitroglycerin (NTG) markedly enhances nitric oxide (NO) bioavailability. However, its ability to mimic the anti-inflammatory properties of NO remains unknown. Here, we examined whether NTG can suppress endothelial cell (EC) activation during inflammation and developed NTG nanoformulation to simultaneously amplify

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