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880160P

Avanti

16:0 PEG2000 PE

Avanti Research™ - A Croda Brand 880160P, powder

Synonym(s):

1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (ammonium salt)

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About This Item

CAS Number:
474922-84-4
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

packaging

pkg of 1 × 1 g (880160P-1g)
pkg of 1 × 200 mg (880160P-200mg)
pkg of 1 × 25 mg (880160P-25mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand 880160P

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCCNC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)(OC(CCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCC)=O.[NH4+]

General description

16:0 PEG2000 PE, also known as 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DPPEmPEG2000), is a polyethylene glycol (mPEG) phospholipid conjugate. Incorporation of PEG-modified lipid conjugates in liposomes facilitates the formation of sterically stabilized liposomes (SSL), which have low reticuloendothelial system (RES) uptake and prolonged circulation lifetimes. These properties aid the PEGylated liposomes to spontaneously deliver drugs to targeted cells.

Application

16:0 PEG2000 PE, or 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] has been used in liposome preparation. It has also been used in preparation of tripeptide arginine-glycine-aspartic acid magnetoliposomes (RGD-MLPs) and poly(ethylene glycol) (PEG)- MLPs.

Packaging

20 mL Clear Glass Screw Cap Vial (880160P-1g)
5 mL Amber Glass Screw Cap Vial (880160P-200mg)
5 mL Amber Glass Screw Cap Vial (880160P-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

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Description
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Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

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Joan Estelrich et al.
ACS omega, 2(10), 6544-6555 (2018-07-20)
We tested the targeting efficiency of magnetoliposomes (MLPs) labeled with tripeptide arginine-glycine-aspartic acid (RGD) on two types of cells: HeLa cells expressing RGD receptors and 3T3 cells lacking RGD receptors. The targeting ability of RGD-MLPs was compared to that of
D Kirpotin et al.
FEBS letters, 388(2-3), 115-118 (1996-06-17)
Plasma-stable liposomes (100 nm) were prepared from dioleoylphosphatidylethanolamine (DOPE) and 3-6 mol% of a new disulfide-linked poly(ethylene glycol)-phospholipid conjugate (mPEG-DTP-DSPE). In contrast to similar preparations containing non-cleavable PEG-phospholipid conjugate, thiolytic cleavage of the grafted polymer chains facilitated rapid and complete
Ilaria Arduino et al.
International journal of pharmaceutics, 583, 119351-119351 (2020-04-28)
Here, polyethylene glycol (PEG)-stabilized solid lipid nanoparticles (SLNs) containing Pt(IV) prodrugs derived from kiteplatin were designed and proposed as novel nanoformulations potentially useful for the treatment of glioblastoma multiforme. Four different Pt(IV) prodrugs were synthesized, starting from kiteplatin by the
Joy Wolfram et al.
Colloids and surfaces. B, Biointerfaces, 114, 294-300 (2013-11-13)
An essential requisite for the design of nanodelivery systems is the ability to characterize the size, homogeneity and zeta potential of nanoparticles. Such properties can be tailored in order to create the most efficient drug delivery platforms. An important question
Kihyeun Kim et al.
Biosensors & bioelectronics, 150, 111885-111885 (2019-11-25)
Solid-phase, single-step biosensors are crucial for the development of portable, reusable, and convenient biosensors, otherwise known as point-of-care (POC) testing. Although high-performance single-step biosensors based on the principle of Förster resonance energy transfer (FRET) and using upconversion nanoparticles (UCNPs) functionalized
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