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Key Documents

201102

Sigma-Aldrich

Bilirubin Conjugate, Ditaurate, Disodium Salt

solid, bilirubin standard, Calbiochem®

Synonym(s):

Bilirubin ditaurate (BDT)

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.77

product name

Bilirubin Conjugate, Ditaurate, Disodium Salt, Bilirubin Conjugate, Ditaurate, Disodium Salt is suitable as a direct bilirubin standard. Behaves similar to purified bilirubin glucuronides from human bile in diazo tests. Unstable in solution.

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

General description

Bilirubin ditaurate (BDT) is the first bile pigment found naturally in the biles of specific fish species. It consists of unconjugated bilirubin (UCB) with taurine side chains attached to the C8 and C12 propionic acids, similar in length to glucuronic acids.

Application

Bilirubin Conjugate, Ditaurate, Disodium Salt has been used to spike patient samples to access icterus interference. It has also been used to prepare test pools for conjugated bilirubin to screen bilirubin interference.
Bilirubin Conjugate, Ditaurate, Disodium Salt – Calbiochem has been used as a standard for testing the interference of conjugated bilirubin in assays aimed at quantifying analytes in serum or plasma samples.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Suitable as a direct bilirubin standard
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Unstable in solution; reconstitute just prior to use.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Self-assembly of aqueous bilirubin ditaurate, a natural conjugated bile pigment, to contraposing enantiomeric dimers and M(-) and P(+) tetramers and their selective hydrophilic disaggregation by monomers and micelles of bile salts
Neubrand MW, et al.
Biochemistry (2015)
A novel canine nuclear magnetic resonance spectroscopy-based metabolomics platform: Validation and sample handling
Ottka C, et al.
Veterinary Clinical Pathology / American Society For Veterinary Clinical Pathology (2021)
Diane M Hamlin et al.
Kidney360, 3(2), 341-356 (2022-04-05)
Symmetric dimethylarginine (SDMA) is an excretory renal function biomarker shown to correlate well with glomerular filtration rate in dogs, cats, humans, and rats. The objectives of this study were to determine utility of serum SDMA as a renal biomarker in
Rising above helium: A hydrogen carrier gas chromatography flame ionization detection (GC-FID) method for the simultaneous quantification of toxic alcohols and ethylene glycol in human plasma specimens
Buse J, et al.
Clinical Biochemistry (2019)
Toan Huynh et al.
Cureus, 9(12), e1965-e1965 (2018-03-02)
Objective We aimed to find new methods to detect and quantify hemolysis and icterus which may cause assay biases. These methods need to determine each of these interferents in the presence of various other interferents. They also need to have

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