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Key Documents

324801

Sigma-Aldrich

Epoxomicin

≥95% (HPLC), liquid, proteasome inhibitor, Calbiochem®

Synonym(s):

InSolution Epoxomicin, Synthetic, Proteasome Inhibitor XIV

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About This Item

Empirical Formula (Hill Notation):
C28H50N4O7
Molecular Weight:
554.72
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Epoxomicin, InSolution, ≥95%

Quality Level

100

Assay

≥95% (HPLC)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

shipped in

wet ice

storage temp.

−20°C

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

A 1 mM (50 µg/90 µl) solution of Epoxomicin, Synthetic (Cat. No. 324800) in DMSO.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Flash Point(C)

87 °C - closed cup - (Dimethylsulfoxide)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates.
Kiss, et al.
Nature Communications, 14, 2160-2160 (2023)
Giulia Pontarollo et al.
Nature metabolism, 5(7), 1174-1187 (2023-07-07)
The gut microbiota influences intestinal barrier integrity through mechanisms that are incompletely understood. Here we show that the commensal microbiota weakens the intestinal barrier by suppressing epithelial neuropilin-1 (NRP1) and Hedgehog (Hh) signaling. Microbial colonization of germ-free mice dampens signaling

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