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Key Documents

AB9078

Sigma-Aldrich

Anti-Ryanodine Receptor 1 Antibody

serum, Chemicon®

Synonym(s):

Anti-CCO, Anti-KDS, Anti-MHS, Anti-MHS1, Anti-PPP1R137, Anti-RYDR, Anti-RYR, Anti-RYR-1, Anti-SKRR

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100 μL
₩693,042

₩693,042


Estimated to ship onFebruary 20, 2025Details


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100 μL
₩693,042

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

clone:
polyclonal
application:
ICC
IHC
WB
species reactivity:
human, mouse, rat
technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
citations:
17

₩693,042


Estimated to ship onFebruary 20, 2025Details


Request a Bulk Order

biological source

rabbit

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human, mouse, rat

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

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This Item
R128HPA056416AB9080
biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

shipped in

dry ice

shipped in

dry ice

shipped in

wet ice

shipped in

dry ice

species reactivity

human, mouse, rat

species reactivity

canine, rabbit, rat, chicken, amphibian, guinea pig, mouse, fish, human

species reactivity

human

species reactivity

mouse, human, rat

technique(s)

immunocytochemistry: suitable, western blot: suitable, immunohistochemistry: suitable

technique(s)

immunohistochemistry (frozen sections): 1 μg/mL using 4% paraformaldehyde-fixed, frozen mouse brain tissue, immunoprecipitation (IP): suitable, western blot (chemiluminescent): 1 μg/mL

technique(s)

immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:50-1:200

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable

Specificity

Ryanodine Receptor 1.

Immunogen

Synthetic peptide from the variant TM region of human Ryanodine Receptor 1.

Application

Anti-Ryanodine Receptor 1 Antibody detects level of Ryanodine Receptor 1 & has been published & validated for use in IC, IH & WB.
Western blot: 1:1,000 using ECL. The antibody reacts with the 500 kDa Ryanodine Receptor 1 protein. Suggested blocking buffer is 10% normal goat serum (or same host as your secondary antibody), 1% BSA in 0.1M PBS with 0.05% Tween 20. Suggested dilution buffer is 1% normal goat serum (or same host as your secondary antibody), 1% BSA in 0.1M PBS with 0.05% Tween 20. Preferred gel percentage is 4-12% gradient gel.

Immunocytochemistry: 1:1,000

Immunohistochemistry: 1:1,000 overnight at 2-8°C using a fluorescently labeled secondary antibody. Suggested fixative is 4% paraformaldehyde in 0.1M PBS (one hour). Suggested permeablization method is 0.05% Triton X-100 in dilution buffer. Suggested blocking buffer is 10% normal goat serum (or same host as your secondary antibody) and 1% BSA in 0.1M PBS. Suggested dilution buffer is 1% normal goat serum (or same host as your secondary antibody) and 1% BSA in 0.1M PBS.

Optimal working dilutions must be determined by the end user.

Analysis Note

Control
Western blot = adult mouse skeletal muscle (adult mouse cardiac muscle will be negative).

IHC = adult mouse cerebellum Purkinje cells (adult mouse cerebellum granular cells will be negative).

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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    Wenli Wang et al.
    Fundamental research, 3(3), 459-468 (2022-03-09)
    Sweet and umami tastes are elicited by sweet and umami receptors on the tongue and palate epithelium, respectively. However, the molecular machinery allowing the taste reaction remains incompletely understood. Through a phosphoproteomic approach, we identified the key proteins that trigger
    Diurnal and nutritional adjustments of intracellular Ca2+ release channels and Ca2+ ATPases associated with restricted feeding schedules in the rat liver.
    Baez-Ruiz, A; Cazares-Gomez, K; Vazquez-Martinez, O; Aguilar-Roblero, R; Diaz-Mu?oz, M
    Journal of circadian rhythms null
    A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.
    Costa, RR; Varanda, WA; Franci, CR
    American Journal of Physiology. Cell Physiology null
    Spaceflight regulates ryanodine receptor subtype 1 in portal vein myocytes in the opposite way of hypertension.
    Dabertrand, F; Porte, Y; Macrez, N; Morel, JL
    Journal of Applied Physiology (1985)
    Topaz Altman et al.
    Journal of cell science, 132(23) (2019-11-15)
    The neuromuscular junction (NMJ) is the largest, most-complex synapse in the human body. Motor neuron (MN) diseases, such as amyotrophic lateral sclerosis (ALS), specifically target MNs and the NMJs. However, little is known about the reasons for MN-selective neuronal and

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