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Key Documents

ED2P

Sigma-Aldrich

Ethylenediaminetetraacetic acid dipotassium salt dihydrate

≥98%

Synonym(s):

(Ethylenedinitrilo)tetraacetic acid dipotassium salt, Dipotassium ethylenediaminetetraacetate dihydrate, EDTA dipotassium salt, Edathamil, Potassium ethylenediaminetetraacetate dibasic

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About This Item

Linear Formula:
HOOCCH2(KOOCCH2)NCH2CH2N(CH2COOK)CH2COOH · 2H2O
CAS Number:
Molecular Weight:
404.45
EC Number:
UNSPSC Code:
12352107
NACRES:
NA.77

biological source

synthetic

Quality Level

Assay

≥98%

form

powder

reaction suitability

reagent type: chelator

pH

4.0-5.0 (25 °C, 40.4 g/L)

mp

255-280 °C (dec.) (lit.)

solubility

3 M KOH: 160 mg/mL, clear to very slightly hazy, colorless to faintly yellow

storage temp.

room temp

SMILES string

O.O.O.O.[K+].[K+].[K+].[K+].OC(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC(O)=O.OC(=O)CN(CCN(CC(O)=O)CC([O-])=O)CC([O-])=O

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Application

Ethylenediaminetetraacetic acid dipotassium salt dehydrate has been used as a component:
  • of EDTA–glycerol solution (EDTA-G) for decalcification[1]
  • of buffer for monoamine and pterine analysis[2]
  • of T-cell resuspension buffer[3]

Used to eliminate inhibition of enzyme catalyzed reactions due to traces of heavy metals

Biochem/physiol Actions

Ethylenediaminetetraacetic acid (EDTA) is an anticoagulant, majorly used in preventing clotting of blood.[4] EDTA may trigger aggregation of platelets resulting in pseudothrombocytopenia.[5] EDTA-tetracycline therapy decreases coronary artery calcium levels in atherosclerosis.[6] Calcium disodium EDTA administration is effective in slowing down the progression of chronic kidney disease.[7] It also enhances the antimicrobial functionality of lysozyme and improves shelf life of cheese.[8]

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Inhalation

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    A novel decalcification method for adult rodent bone for histological analysis of peripheral-central nervous system connections
    Begum F, et al.
    Journal of Neuroscience Methods, 187(1), 59-66 (2010)
    Cytochrome c oxidase activity is a metabolic checkpoint that regulates cell fate decisions during T cell activation and differentiation
    Tarasenko TN, et al.
    Cell Metabolism, 25(6), 1254-1268 (2017)
    Whole body insulin responsiveness is higher in beef steers selected for increased muscling
    McGilchrist P, et al.
    Animal : An International Journal of Animal Bioscience, 5(10), 1579-1586 (2011)
    Calcification in coronary artery disease can be reversed by EDTA-tetracycline long-term chemotherapy
    Maniscalco BS and Taylor KA
    Pathophysiology : The Official Journal of the International Society for Pathophysiology / ISP, 11(2), 95-101 (2004)
    Does calcium disodium EDTA slow CKD progression?
    Weaver VM, et al.
    American Journal of Kidney Diseases, 60(4), 503-506 (2012)

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