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PHR1854

Supelco

Candesartan Cilexetil

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Candesartan cilexetil, 2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-Benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester, TCV 116, TCY 116

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About This Item

Empirical Formula (Hill Notation):
C33H34N6O6
CAS Number:
Molecular Weight:
610.66
MDL number:
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material
pharmaceutical secondary standard

Quality Level

Agency

traceable to Ph. Eur. Y0001388
traceable to USP 1087803

API family

candesartan

form

powder

packaging

pkg of 200 mg

application(s)

pharmaceutical

SMILES string

CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc4ccc(cc4)-c5ccccc5-c6nnn[nH]6

InChI

1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)

InChI key

GHOSNRCGJFBJIB-UHFFFAOYSA-N

Gene Information

human ... AGTR1(185)

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General description

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Candesartan cilexetil is an angiotensin II receptor antagonist used as a prodrug in the treatment of hypertension.

Application

This pharmaceutical secondary standard can also be used as follows:

  • Determination of candesartan cilexetil in tablet formulations by a UV/fluorescence spectrophotometric method
  • Study of the release of candesartan cilexetil in tablet form by reversed-phase high-performance liquid chromatography (RP-HPLC)
  • Simultaneous estimation of candesartan cilexetil and hydrochlorothiazide in pharmaceutical preparations using liquid chromatography in combination with photodiode array detector (DAD) and evaporative light scattering detector (ELSD)
  • Spectroflourimetric determination of four angiotensin II receptor antagonists (AIIRA’s) in their pure form as well as pharmaceutical formulations

Biochem/physiol Actions

Candesartan cilexetil is the prodrug form of the potent angiotensin II receptor antagonist, candesartan. The prodrug is cleaved by esterases within the intestine to liberate the active molecule.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAB8504 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

Recommended products

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

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Pricing

Pictograms

Health hazard

Signal Word

Danger

Hazard Statements

Hazard Classifications

Repr. 1B - STOT RE 2 Oral

Target Organs

Kidney,Blood

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Flow injection spectrophotometric and spectrofluorimetric methods for the determination of candesartan cilexetil in pharmaceutical formulations
Ayisha K, et al.
Scientific Research and Essays, 6, 6203-6208 (2011)
Development and validation of a dissolution test with reversed-phase high performance liquid chromatographic analysis for Candesartan cilexetil in tablet dosage forms
Kamalakkannan V, et al.
Arabian Journal of Chemistry, 9, S867-S873 (2016)

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