51800C
Claycomb Medium
without L-glutamine, liquid, sterile-filtered, suitable for cell culture
Synonym(s):
HL-1 Medium
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About This Item
UNSPSC Code:
12352207
NACRES:
NA.75
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description
For research or for further manufacturing use.
sterility
sterile-filtered
form
liquid
storage condition
protect from light
technique(s)
cell culture | mammalian: suitable
components
L-glutamine: no
shipped in
ambient
storage temp.
2-8°C
Related Categories
Application
Claycomb Medium, named after Dr. William Claycomb who established the HL-1 cell line, is specifically designed for the growth of murine cardiomyocytes. HL-1 is the first cell line established that can maintain the differentiated cardiomyocyte phenotype and contractile activity in vitro. The HL-1 cell line can be used for the study of cardiac cell hypertrophy that follows myocardial infarction, the testing of novel cardiac therapeutic drugs and treatments, the production of high levels of cardiac proteins and the study of mature cardiomyocyte specific genes. Claycomb Medium, when supplemented with 100 μM norepinephrin, 10% fetal bovine serum (FBS) and 4 mM L-glutamine, will maintain the HL-1 cell line and the mature cardiomycyte behavior. While observing the HL-1 cells under light microscopy, individual and groups of cells can be observed contracting, becoming more frequent as the cardiomyocytes reach confluency.
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Storage Class Code
12 - Non Combustible Liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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L A Sikkink et al.
Cell death & disease, 1, e98-e98 (2010-01-01)
Light-chain amyloidosis (AL) is a devastating protein-misfolding disease characterized by abnormal proliferation of plasma cells in the bone marrow that secrete monoclonal immunoglobulin light chains that misfold and form amyloid fibrils, thus causing organ failure and death. Numerous reports on
Jan Hendrik van Weerd et al.
eLife, 9 (2020-07-17)
Genome-wide association studies have implicated common genomic variants in the gene desert upstream of TBX3 in cardiac conduction velocity. Whether these noncoding variants affect expression of TBX3 or neighboring genes and how they affect cardiac conduction is not understood. Here
Ivana Poparic et al.
PloS one, 6(10), e26524-e26524 (2011-11-05)
Four-and-a-half LIM domain protein 1 isoform A (FHL1A) is predominantly expressed in skeletal and cardiac muscle. Mutations in the FHL1 gene are causative for several types of hereditary myopathies including X-linked myopathy with postural muscle atrophy (XMPMA). We here studied
Malou van den Boogaard et al.
Cell reports, 28(10), 2704-2714 (2019-09-05)
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Yaopeng Hu et al.
Pflugers Archiv : European journal of physiology, 473(3), 507-519 (2021-01-05)
TRPM4 is a Ca2+-activated nonselective cation channel involved in cardiovascular physiology and pathophysiology. Based on cellular experiments and numerical simulations, the present study aimed to explore the potential arrhythmogenicity of CaMKII-mediated TRPM4 channel overactivation linked to Ca2+ dysregulation in the
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