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A2691

Sigma-Aldrich

Anti-Human IgA (α-chain specific)−Agarose antibody produced in goat

affinity isolated antibody, adsorbed with mouse and rat IgG

Synonym(s):

Goat Anti-Human IgA

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

goat

Quality Level

conjugate

agarose conjugate

antibody form

affinity isolated antibody

antibody product type

secondary antibodies

clone

polyclonal

form

PBS suspension

species reactivity

human

should not react with

rat, mouse

capacity

3-4 mg/mL binding capacity (human IgA)

storage temp.

2-8°C

target post-translational modification

unmodified

General description

Binding Capacity: One mL of antibody binds 3-4 mg human IgA. Elution Capacity is 2-4 mg/mL.
IgA antibody plays an essential role in mucosal immunity. It has shown to bind immunogens/pathogens to restrict them from entering the mucosal membrane. The Anti-Human IgA (α-chain specific) product increases sensitivity to human IgA without cross-reactivity to other substances. Offering minimal interspecies cross reactivity to mouse or a rat, making it ideal for use in screening antibodies produced by a hybridoma cells containing a mouse or a rat immunoglobulins.

Immunogen

IgA produced from transformed cell line of human Epstein-Barr virus.

Application

Affinity chromatography using anti-human IgA antibody linked to agarose was performed to purify proteins from 2E9IgA1 transfectant cells.
Anti-Human IgA (α-chain specific)-Agarose antibody produced in goat has been used in affinity chromatography and quantitative enzyme linked immunosorbent assay (ELISA).

Physical form

Suspension in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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Florian Erger et al.
Proceedings of the National Academy of Sciences of the United States of America, 120(22), e2211087120-e2211087120 (2023-05-22)
Mutations in genes encoding molecular chaperones can lead to chaperonopathies, but none have so far been identified causing congenital disorders of glycosylation. Here we identified two maternal half-brothers with a novel chaperonopathy, causing impaired protein O-glycosylation. The patients have a
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Garderet L, et al.
Leukemia & Lymphoma, 47(7), 1340-1347 (2006)
M Kristen Demoruelle et al.
Arthritis research & therapy, 23(1), 163-163 (2021-06-08)
Mucosal sites are hypothesized to play a role in the development of rheumatoid arthritis (RA). Since serum anti-peptidylarginine deiminase (PAD)4 antibodies, including a subset that cross-react with PAD3 (PAD3/4), are specific for RA and associate with severe disease, we sought
Yasuyuki Matsumoto et al.
Science advances, 8(43), eabm8783-eabm8783 (2022-10-29)
The underlying pathology of immunoglobulin A (IgA) nephropathy (IgAN), the most common glomerulonephritis worldwide, is driven by the deposition of immune complexes containing galactose-deficient IgA1 [Tn(+)IgA1] in the glomerular mesangium. Here, we report that novel anti-Tn circulating immune complexes (anti-Tn
Yuanyi Yue et al.
Frontiers in immunology, 12, 758040-758040 (2022-02-11)
The tumor microenvironment (TME) plays an important role in the pathogenesis of many cancers. We aimed to screen the TME-related hub genes of colorectal adenoma (CRAD) and identify possible prognostic biomarkers. The gene expression profiles and clinical data of 464

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