F0850
Fetal Bovine Serum
Synonym(s):
Fetal Bovine Sera, Fetal Calf Serum
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About This Item
UNSPSC Code:
12352207
eCl@ss:
32160409
NACRES:
NA.71
Recommended Products
biological source
bovine fetus
sterility
sterile-filtered
product line
FBS Classic
composition
Bovine IgG, ≤1 mg/mL
Hemoglobin, ≤20 mg/dL
origin
USA origin
technique(s)
cell culture | hybridoma: suitable
cell culture | mammalian: suitable
impurities
≤10 EU/mL endotoxin
shipped in
dry ice
storage temp.
−20°C
General description
Fetal Bovine Serum (FBS) is a complex mixture with low and high molecular weight biomolecules exhibiting optimal growth-enhancing and growth-suppressing functions. FBS contains molecules, such as growth factors, proteins, vitamins, trace elements, hormones etc. These molecules are important for the growth and maintenance of cells. It is a common supplement for cell culture media.citationcitation FBS is derived from the calf blood. It is devoid of fibrin and clotting factors. Heat inactivation of FBS blocks the complement system.citation FBS derived from clotted blood is the most widely used undefined supplement in eukaryotic, especially mammalian, cell culture.citationcitation It is typically used with the classical media that were developed in the 1950s and 1960s. These include many popular media such as Minimum Essential Medium (MEM),citation Dulbecco′s Modified Eagles Media (DME, DMEM); Iscove′s Modified Eagles Medium (IMDM),citation M199citation and Roswell Park Memorial Institute medium, RPMI-1640.citation
Application
- tested for the presence of bacteria, virus, mycoplasma, endotoxin and for hemoglobin content
- triple filtered with 0.1 micron membrane under aseptic conditions
FBS derived from clotted blood is the most widely used undefined supplement in eukaryotic, especially mammalian, cell culture. It is typically used with the classical media that were developed in the 1950s and 1960s. These include many popular media such as Minimum Essential Medium (MEM); Dulbecco′s Modified Eagles Media (DME, DMEM); Iscove′s Modified Eagles Medium (IMDM); M199 and Roswell Park Memorial Institute medium, RPMI-1640.
Fetal Bovine Serum has also been used as a component of:
- perivascular-resident macrophage-like melanocytes (PVM/M) growth mediumcitation
- synthetic oviduct fluid (SOF)citation
- Eagle′s minimum essential medium (EMEM)citation
- neurobasal mediumcitation
- Hyclone McCoys 5 A mediumcitation
- Hanks mediumcitation
Biochem/physiol Actions
FBS remains a popular media supplement because it provides a wide array of functions in cell culture. FBS delivers nutrients, growth and attachment factors and protects cells from oxidative damage and apoptosis by mechanisms that are difficult to reproduce in serum-free media (SFM) systems.
Analysis Note
- Tested for the presence of bacteria, virus, and mycoplasma
- Triple filtered with 0.1 micron membrane under aseptic conditions
Other Notes
Tested for the presence of bacteria, virus, mycoplasma, endotoxin and for hemoglobin content. Triple filtered with 0.1 micron membrane under aseptic conditions.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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