Skip to Content
Merck
All Photos(1)

Key Documents

G5172

Sigma-Aldrich

GW4064

≥97% (HPLC)

Synonym(s):

3-(2,6-Dichlorophenyl)-4-(3’-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole

Sign Into View Organizational & Contract Pricing

Select a Size

1 EA
$133.00

$133.00


In StockDetails


Request a Bulk Order

Select a Size

Change View
1 EA
$133.00

About This Item

Empirical Formula (Hill Notation):
C28H22Cl3NO4
CAS Number:
Molecular Weight:
542.84
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32

$133.00


In StockDetails


Request a Bulk Order

Quality Level

Assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC(C)c1onc(c1COc2ccc(\C=C\c3cccc(c3)C(O)=O)c(Cl)c2)-c4c(Cl)cccc4Cl

InChI

1S/C28H22Cl3NO4/c1-16(2)27-21(26(32-36-27)25-22(29)7-4-8-23(25)30)15-35-20-12-11-18(24(31)14-20)10-9-17-5-3-6-19(13-17)28(33)34/h3-14,16H,15H2,1-2H3,(H,33,34)/b10-9+

InChI key

BYTNEISLBIENSA-MDZDMXLPSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
N9005N912533461
Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

200

form

powder

form

solid

form

powder

form

powder

mp

98-100 °C (lit.)

mp

47-50 °C (lit.)

mp

194-198 °C (dec.) (lit.)

mp

194-198 °C (dec.) (lit.)

General description

GW4064 is a synthetic isoxazole, which is used to decipher the cellular and physiological functions of farnesoid X receptor (FXR). It is an estrogen receptor-related receptors (ERRs) agonist.[1]

Application

GW4064 has been used:
  • to investigate its ability to protect the livers of mice from lipopolysaccharide (LPS)-induced inflammation and apoptosis[2]
  • to examine its capability to inhibit mucosal injury in ileum caused by lipopolysaccharide (LPS)[3]
  • to treat ileal explants[4]

Biochem/physiol Actions

GW4064 is a FXR agonist. GW4064 is a potent (EC50 = 15 nM), non-steroidal agonist of the orphan nuclear receptor FXR. It shows no activity on other nuclear receptors including RAR up to 1 mM. This is an important tool for the study of the involvment of FXR in a variety of biological activities.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 4 - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Synthetic FXR Agonist GW4064 Is a Modulator of Multiple G Protein-Coupled Receptors
Singh N, et al.
Molecular Endocrinology, 28(5), 659-673 (2014)
Bile acid administration elicits an intestinal antimicrobial program and reduces the bacterial burden in two mouse models of enteric infection
Tremblay S, et al.
Infection and Immunity, 85(6), e00942-e00916 (2017)
Xiang Jiang et al.
Journal of autoimmunity, 90, 64-75 (2018-02-13)
Mucosal-associated invariant T (MAIT) cells are novel innate-like T cells constituting a significant proportion of circulating and hepatic T cells. Herein, we extensively examine the phenotypical and functional alterations of MAIT cells and their regulation in a cohort of 56
Qixiao Zhai et al.
Food & function, 10(3), 1455-1464 (2019-02-16)
The management of lead (Pb) exposure and toxicity remains a major public health priority worldwide. In our previous study, the probiotic strain Lactobacillus plantarum CCFM8661 prevented Pb absorption in mice via intestinal sequestration. This follow-up study aimed to evaluate the
Jing Yang et al.
Frontiers in pharmacology, 8, 260-260 (2017-05-26)
Triptolide (TP), a diterpenoid isolated from

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service