H2504
His-Leu
≥98% (TLC), suitable for ligand binding assays
Synonym(s):
histidylleucine
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Product Name
His-Leu,
Assay
≥98% (TLC)
Quality Level
form
solid
technique(s)
ligand binding assay: suitable
color
white to off-white
storage temp.
−20°C
SMILES string
CC(C)CC(NC(=O)C(N)Cc1cnc[nH]1)C(O)=O
InChI
1S/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)
InChI key
MMFKFJORZBJVNF-UHFFFAOYSA-N
Related Categories
Biochem/physiol Actions
Histidylleucine (His-Leu); histidylglycine (His-Gly) and histidylserine (His-Ser) are N-terminal imidazole containing dipeptides used to study binding of metals such as copper, nickel and zinc.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Clinical and experimental pharmacology & physiology, 20(7-8), 501-507 (1993-07-01)
1. The effects of peptide histidine isoleucine (PHI) on pancreatic exocrine secretion were investigated in preparations of the isolated and blood-perfused dog pancreas as compared with those of vasoactive intestinal peptide (VIP), secretin and glucagon. 2. Each peptide tested was
Identification of enzymatically produced peptide fragments by liquid chromatography and mass spectrometry.
Analytical biochemistry, 121(1), 97-102 (1982-03-15)
Neuroendocrinology, 49(3), 309-323 (1989-03-01)
The distribution of several peptides, corticotropin-releasing factor (CRF), neurotensin (NT), enkephalin (ENK), vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), cholecystokinin (CCK), thyrotropin-releasing hormone (TRH) and galanin (GAL) was studied in detail with immunohistochemistry in the various subdivisions of the
Scandinavian journal of clinical and laboratory investigation, 54(2), 105-111 (1994-04-01)
The importance of skeletal muscle for human haemodynamics and metabolism makes it a suitable sample tissue for the measurement of angiotensin converting enzyme (ACE; EC 3.4.15.1). A study of serum and muscle angiotensin-converting enzyme was performed in 50 essential-hypertensive subjects.
Peptides, 7(1), 127-133 (1986-01-01)
Bombesin-like immunoreactivity (BLI) has been demonstrated in neurons of the gastrointestinal tract and gastric BLI secretion can be demonstrated in response to the classical neurotransmitter acetylcholine. Since structurally related peptides VIP, PHI and GRF have to be considered as peptidergic
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