MAK529
LDH Cytotoxicity Assay Kit
sufficient for 100 colorimetric tests
Synonym(s):
LDH-Cytotoxicity Test Kit II
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About This Item
UNSPSC Code:
12161503
NACRES:
NA.84
Recommended Products
Quality Level
detection method
colorimetric
relevant disease(s)
hematological disorder; cancer
shipped in
wet ice
storage temp.
−20°C
General description
Lactate dehydrogenase (LDH) is an oxidoreductase which catalyzes the interconversion of lactate and pyruvate. Cytotoxic compounds often compromise cell membrane integrity by inducing apoptosis or necrosis. LDH is a stable cytosolic enzyme, that upon membrane damage, is released into the cellular environment. Therefore, LDH is often measured to evaluate the presence of tissue or cell damage.
Features and Benefits
- Compatible with high-throughput handling systems.
Suitability
The kit is suitable for the rapid quantitative determination of cytotoxicity based on lactate dehydrogenase released into cell culture medium, and for the evaluation of toxic compounds, toxins, detergents, environmental pollutants and physical treatment on cell lysis.
Principle
The LDH Cytotoxicity Assay Kit is a simple and robust method to assess cytotoxic effects on cells by measuring the activity of LDH in cell culture supernatant. The assay is based on the reduction of a tetrazolium salt to a formazan dye.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Certificates of Analysis (COA)
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