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O7125

Sigma-Aldrich

L-Ornithine L-aspartate salt

≥98% (TLC)

Synonym(s):

(S)-2,5-Diaminopentanoic acid L-aspartate salt

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25 ML
$391.00

$391.00


Estimated to ship onMarch 21, 2025


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25 ML
$391.00

About This Item

Empirical Formula (Hill Notation):
C9H19N3O6
CAS Number:
Molecular Weight:
265.26
EC Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

$391.00


Estimated to ship onMarch 21, 2025


Request a Bulk Order

Product Name

L-Ornithine L-aspartate salt, powder

Assay

≥98% (TLC)

Quality Level

form

powder

color

white to off-white

storage temp.

2-8°C

SMILES string

NCCC[C@H](N)C(O)=O.N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C5H12N2O2.C4H7NO4/c6-3-1-2-4(7)5(8)9;5-2(4(8)9)1-3(6)7/h4H,1-3,6-7H2,(H,8,9);2H,1,5H2,(H,6,7)(H,8,9)/t4-;2-/m00/s1

InChI key

IXUZXIMQZIMPSQ-ZBRNBAAYSA-N

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SYNPLE-BT033SYNPLE-BT034SYNPLE-BT024
parameter

up to 0.1 mmol scale

parameter

up to 0.1 mmol scale

parameter

up to 0.1 mmol scale

parameter

up to 0.1 mmol scale

Biochem/physiol Actions

L-Ornithine L-aspartate is a metabolite of arginine degradation by arginase. It has been shown to reduce blood ammonia concentrations by increasing ammoniadetoxification in the muscle and reducing the severity of hepatic encephalopathy in cirrhosis.

Other Notes

Product of arginine degradation by arginase

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Qian Jiang et al.
    Journal of gastroenterology and hepatology, 24(1), 9-14 (2008-10-01)
    Hepatic encephalopathy continues to be a major clinical problem and the current decade has not witnessed major therapeutic breakthroughs in this area. L-ornithine-l-aspartate (LOLA) is not frequently used as there are still some reservations about its benefits. The present study
    Patrícia Coelho de Soárez et al.
    Arquivos de gastroenterologia, 46(3), 241-247 (2009-11-18)
    Experimental and clinical studies suggest that LOLA may have a favorable influence on hepatic encephalopathy due to the effect on the reduction of ammonia, and improvement of the symptoms and laboratory findings. To evaluate and to critically analyze the efficacy
    Bin Zhang et al.
    Bioresource technology, 284, 204-213 (2019-04-03)
    l-ornithine, an important amino acid, is widely used in food and medicine industries. l-ornithine production mainly relies on microbial fermentation, which may not meet the industrial requirement owing to the poor fermentation ability of available strains. Herein, mscCG2 deletion, CgS9114_12202
    Janus P Ong et al.
    Clinical drug investigation, 31(4), 213-220 (2011-01-07)
    Hepatic encephalopathy (HE) is a serious complication of cirrhosis. Clinical trials have consistently shown that L-ornithine-L-aspartate significantly improves HE symptoms. Health-related quality of life (HR-QOL) is impaired in HE patients and represents an important outcome measure for therapeutic intervention. The
    Vibhu Vibhas Mittal et al.
    European journal of gastroenterology & hepatology, 23(8), 725-732 (2011-06-08)
    Minimal hepatic encephalopathy (MHE) impairs daily functioning and health-related quality of life (HRQoL). The modalities of treatment of MHE have not been adequately studied. To compare lactulose, probiotics, and L-ornithine L-aspartate (LOLA) in treatment of MHE and effect on HRQoL

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