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P2534

Sigma-Aldrich

Poly-L-histidine hydrochloride

mol wt ≥5000

Synonym(s):

L-Histidine homopolymer hydrochloride

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$403.00

About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26

$403.00


Estimated to ship onMay 12, 2025


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form

powder

Quality Level

mol wt

≥5000

color

white to very light yellow

storage temp.

−20°C

SMILES string

N[C@H](Cc1c[nH]cn1)C(O)=O

InChI key

HNDVDQJCIGZPNO-RXMQYKEDSA-N

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1 of 4

This Item
C9995C0871C7117
Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

technique(s)

indirect immunofluorescence: 10-20 μg/mL using HeLa cells, western blot: 1-2 μg/mL using HEK-293T cells expressing human Cullin-4A

technique(s)

western blot: 0.7-1.5 μg/mL using HEK-293T cells expressing human Cullin-4B.

technique(s)

immunoprecipitation (IP): 5-10 μg using lysate of rat brain, indirect immunofluorescence: 5-10 μg/mL using mouse 3T3 cells, western blot: 1-2 μg/mL using whole extract of HEK-293T cells expressing human Cullin 3

technique(s)

western blot: 0.5-1 μg/mL using whole cell extract of human colon carcinoma HCT-116 cell line and whole cell extract of mouse fibroblasts NIH3T3 cell line

UniProt accession no.

Q13619

UniProt accession no.

Q13620

UniProt accession no.

Q13618

UniProt accession no.

Q13616

Analysis Note

Molecular weight by MALLS.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Carboxymethyl poly(L-histidine) as a new pH-sensitive polypeptide to enhance polyplex gene delivery.
    Asayama S, Sudo M, et al.
    Molecular Pharmacology, 5, 898-901 (2008)
    J M Benns et al.
    Bioconjugate chemistry, 11(5), 637-645 (2000-09-20)
    Advancing biotechnology spurs the development of new pharmaceutically engineered gene delivery vehicles. Poly(L-histidine) ¿PLH¿ has been shown to induce membrane fusion at endosomal pH values, whereas PLL has a well documented efficacy in polyplex formation. Therefore, N-Ac-poly(L-histidine)-graft-poly(L-lysine) ¿PLH-g-PLL¿ was synthesized
    Pablo R Dalmasso et al.
    Analytica chimica acta, 710, 58-64 (2011-11-30)
    We report for the first time the use of polyhistidine (Polyhis) to efficiently disperse multiwall carbon nanotubes (MWCNTs). The optimum dispersion MWCNT-Polyhis was obtained by sonicating for 30 min 1.0 mg mL(-1) MWCNTs in 0.25 mg mL(-1) Polyhis solution prepared

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